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Last Updated: June 30, 2022

CLINICAL TRIALS PROFILE FOR ALLEGRA HIVES


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All Clinical Trials for Allegra Hives

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00103012 ↗ Drug Interactions of Echinacea, Ginseng, and Ginkgo Biloba Taken With Lopinavir/Ritonavir in Healthy Volunteers Completed National Institutes of Health Clinical Center (CC) Phase 4 2005-01-01 This study will examine the interaction of the HIV combination medication lopinavir/ritonavir with the herbal products echinacea, ginseng, and ginkgo biloba. Patients with HIV infection often take herbal products and dietary supplements in addition to their doctor-prescribed medicines to treat the disease, lessen the side effects of anti-viral drugs, and improve their overall well being. Alternative medicines such as these may, however, interfere with the elimination of lopinavir/ritonavir from the body, causing either higher or lower blood levels of these drugs than would be expected. This study will assess in healthy subjects any potential harms of taking echinacea, ginseng, or ginkgo biloba together with lopinavir/ritonavir. Healthy normal volunteers between 18 and 50 years of age may be eligible for this study. Candidates are screened with a history, physical examination, and blood tests, including an HIV test and a pregnancy test for women. Pregnant women are excluded from the study. Participants come to the NIH Clinical Center after fasting overnight for the following procedures: Visits 1 and 2: A catheter (plastic tube) is placed in an arm vein to collect blood samples. After the first sample is drawn, the subject takes 8 mg of midazolam syrup and two fexofenadine tablets. Midazolam is a sedative, and fexofenadine (Allegra) is a medicine used to treat allergies. Subjects are given breakfast an hour after taking the drugs. Blood samples are collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8 and 24 hours after taking the drugs to measure blood levels of fexofenadine. An extra sample is collected at the 4-hour mark to measure the midazolam level. The catheter is removed after the 8-hour blood draw and subjects are dismissed home. They return the following morning (visit 2) for the 24-hour blood draw. Visit 3: From 7 to 28 days after visit 1, subjects begin taking lopinavir/ritonavir capsules twice a day by mouth for a total of 29.5 days. On day 15 they return to the clinic for lopinavir/ritonavir blood levels as were done for fexofenadine, except that samples are collected once before breakfast and then at 0.5, 1, 2, 3, 4, 6, 8 and 12 hours after the lopinavir/ritonavir dose. An extra sample is collected for routine tests. The catheter is removed after the 12-hour draw and the subject is dismissed home. The next morning, subjects begin taking one of the following: echinacea 500 mg 3 times a day; ginkgo biloba 120 mg twice a day; or ginseng 500 mg 3 times a day for 28 days. Visit 4: On the last day of taking lopinavir/ritonavir, subjects return to the clinic again for blood level measurements of these drugs as on visit 3, except that the catheter is removed and the subject dismissed home after the 8-hour blood draw. Visits 5 and 6: On the last day of taking the herbal supplement, subjects return to the clinic for repeat measurement of fexofenadine and midazolam levels, as described in visits 1 and 2. At the final visit (visit 6) an additional blood sample is collected for repeat laboratory testing. ...
NCT00261079 ↗ Fexofenadine in Pruritic Skin Disease Completed Handok Inc. Phase 4 2005-04-01 Primary objective: - To compare the efficacy and safety profile of Fexofenadine 180mg tablets plus prednicarbate(2.5mg/g) vs prednicarbate(2.5mg/g) alone in the treatment of pruritic skin disease Secondary objective: - To evaluate patient's satisfaction of Allegra treatment
NCT00261079 ↗ Fexofenadine in Pruritic Skin Disease Completed Handok Pharmaceuticals Co., Ltd. Phase 4 2005-04-01 Primary objective: - To compare the efficacy and safety profile of Fexofenadine 180mg tablets plus prednicarbate(2.5mg/g) vs prednicarbate(2.5mg/g) alone in the treatment of pruritic skin disease Secondary objective: - To evaluate patient's satisfaction of Allegra treatment
NCT00420082 ↗ A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber Completed Faes Farma, S.A. Phase 2 2006-10-01 This is a randomized, double blind, active and placebo controlled, 4 way crossover study in patients with seasonal allergic rhinitis. Patients will receive a single dose of bilastine 20 mg, Cetirizine 10 mg, Fexofenadine 120 mg, and placebo in the Vienna Challenge Chamber.
NCT00562120 ↗ A Study to Test a New Decongestant in Patients With Allergic Rhinitis Following a Nasal Allergen Challenge Completed Pfizer Phase 2 2007-12-01 An H3 receptor antagonist should reduce the congestion associated with allergic rhinitis. A nasal allergen challenge will be given to patients to induce rhinitis symptoms and acoustic rhinometry will be used to measure the congestion.
NCT00636870 ↗ Fexofenadine (Allegra┬«) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine Completed Sanofi Phase 4 2003-02-01 To evaluate the single-dose and steady-state pharmacokinetics of desloratadine and fexofenadine in desloratadine slow metabolizers. To evaluate the safety and tolerability of desloratadine compared to fexofenadine following single and multiple oral doses administered to desloratadine slow metabolizers.
NCT00637585 ↗ Fexofenadine HCl 180 mg, Desloratadine 5 mg and Placebo in Suppression of Wheal and Flare Induced by Histamine Completed Sanofi Phase 4 2002-12-01 To examine the relative potency, onset of action and duration of action of fexofenadine HCl 180 mg (ALLEGRA) and desloratadine 5 mg (CLARINEX) as compared to placebo on skin wheals and flares induced by histamine.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Allegra Hives

Condition Name

Condition Name for Allegra Hives
Intervention Trials
Healthy 10
Seasonal Allergic Rhinitis 6
Allergic Rhinitis 5
Rhinitis Seasonal 2
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Condition MeSH

Condition MeSH for Allegra Hives
Intervention Trials
Rhinitis, Allergic 15
Rhinitis 15
Rhinitis, Allergic, Seasonal 8
Eczema 2
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Clinical Trial Locations for Allegra Hives

Trials by Country

Trials by Country for Allegra Hives
Location Trials
United States 14
Canada 4
India 3
Japan 3
Austria 1
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Trials by US State

Trials by US State for Allegra Hives
Location Trials
New Jersey 3
North Dakota 2
West Virginia 2
California 1
Utah 1
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Clinical Trial Progress for Allegra Hives

Clinical Trial Phase

Clinical Trial Phase for Allegra Hives
Clinical Trial Phase Trials
Phase 4 12
Phase 3 3
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Allegra Hives
Clinical Trial Phase Trials
Completed 30
Recruiting 2
Not yet recruiting 1
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Clinical Trial Sponsors for Allegra Hives

Sponsor Name

Sponsor Name for Allegra Hives
Sponsor Trials
Sanofi 7
Merck Sharp & Dohme Corp. 5
Dr. Reddy's Laboratories Limited 5
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Sponsor Type

Sponsor Type for Allegra Hives
Sponsor Trials
Industry 29
Other 8
U.S. Fed 1
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