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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR ALENDRONATE SODIUM

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Clinical Trials for Alendronate Sodium

Trial ID Title Status Sponsor Phase Summary
NCT00000412 Osteoporosis Prevention After Heart Transplant Completed Merck Sharp & Dohme Corp. Phase 3 During the first year after a heart transplant, people often rapidly lose bone from their spine and hips. About 35 percent of people who receive heart transplants will suffer broken bones during the first year after transplantation. This study will compare the safety and effectiveness of the drug alendronate (Fosamax) and the active form of vitamin D (calcitriol) in preventing bone loss at the spine and hip after a heart transplant. In this study, people who have had a successful heart transplant will receive either active alendronate and a "dummy pill" instead of calcitriol, or active calcitriol and a dummy pill instead of alendronate for the first year after their transplant, starting within 1 month after transplant surgery. We will measure bone density in the hip and spine at the start of the study and after 6 and 12 months, and will also check for broken bones in the spine. This research should lead to ways of preventing this crippling form of osteoporosis.
NCT00000412 Osteoporosis Prevention After Heart Transplant Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 3 During the first year after a heart transplant, people often rapidly lose bone from their spine and hips. About 35 percent of people who receive heart transplants will suffer broken bones during the first year after transplantation. This study will compare the safety and effectiveness of the drug alendronate (Fosamax) and the active form of vitamin D (calcitriol) in preventing bone loss at the spine and hip after a heart transplant. In this study, people who have had a successful heart transplant will receive either active alendronate and a "dummy pill" instead of calcitriol, or active calcitriol and a dummy pill instead of alendronate for the first year after their transplant, starting within 1 month after transplant surgery. We will measure bone density in the hip and spine at the start of the study and after 6 and 12 months, and will also check for broken bones in the spine. This research should lead to ways of preventing this crippling form of osteoporosis.
NCT00000412 Osteoporosis Prevention After Heart Transplant Completed Columbia University Phase 3 During the first year after a heart transplant, people often rapidly lose bone from their spine and hips. About 35 percent of people who receive heart transplants will suffer broken bones during the first year after transplantation. This study will compare the safety and effectiveness of the drug alendronate (Fosamax) and the active form of vitamin D (calcitriol) in preventing bone loss at the spine and hip after a heart transplant. In this study, people who have had a successful heart transplant will receive either active alendronate and a "dummy pill" instead of calcitriol, or active calcitriol and a dummy pill instead of alendronate for the first year after their transplant, starting within 1 month after transplant surgery. We will measure bone density in the hip and spine at the start of the study and after 6 and 12 months, and will also check for broken bones in the spine. This research should lead to ways of preventing this crippling form of osteoporosis.
NCT00004488 Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher's Disease Completed Children's Hospital Medical Center, Cincinnati Phase 2 OBJECTIVES: I. Determine the efficacy of alendronate sodium in treating osteopenia (generalized bone density and focal bone lesions) in patients with Gaucher's disease.
NCT00005006 Parathyroid Hormone (PTH) With Alendronate for Osteoporosis Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 2 This study investigates the effectiveness of parathyroid hormone (PTH) in combination with alendronate, a standard treatment for osteoporosis that blocks or reduces bone loss. We are using alendronate because it may help protect patients against any possible harmful effects of PTH in cortical bone such as the long bones or hip. We are testing two different treatment schedules of PTH-one in which we give PTH daily and one in which we give PTH for 3 out of every 6 months in a cyclical fashion. The entire study is 21 months long; the active treatment period is 18 months with a 6-month followup period. The main effects we will look for in this study are changes in body chemicals that are signs of bone formation or bone breakdown, and changes in bone density throughout the skeleton. We will randomly assign all study participants, who are women aged 50 and over, to either stay on alendronate alone, receive daily continuous PTH plus alendronate, or receive daily PTH for 3 months out of every 6 for a total of three separate 3-month cycles of PTH plus daily alendronate.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Alendronate Sodium

Condition Name

Condition Name for Alendronate Sodium
Intervention Trials
Osteoporosis 10
Healthy 4
Postmenopausal Osteoporosis 3
Osteopenia 2
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Condition MeSH

Condition MeSH for Alendronate Sodium
Intervention Trials
Osteoporosis 16
Osteoporosis, Postmenopausal 5
Bone Diseases, Metabolic 2
Thyroid Diseases 1
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Clinical Trial Locations for Alendronate Sodium

Trials by Country

Trials by Country for Alendronate Sodium
Location Trials
United States 12
China 1
Israel 1
Denmark 1
Canada 1
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Trials by US State

Trials by US State for Alendronate Sodium
Location Trials
North Dakota 3
South Carolina 2
New York 2
Wisconsin 1
Colorado 1
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Clinical Trial Progress for Alendronate Sodium

Clinical Trial Phase

Clinical Trial Phase for Alendronate Sodium
Clinical Trial Phase Trials
Phase 4 3
Phase 3 9
Phase 2 6
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Clinical Trial Status

Clinical Trial Status for Alendronate Sodium
Clinical Trial Phase Trials
Completed 20
Recruiting 2
Withdrawn 1
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Clinical Trial Sponsors for Alendronate Sodium

Sponsor Name

Sponsor Name for Alendronate Sodium
Sponsor Trials
Merck Sharp & Dohme Corp. 10
Medical University of South Carolina 2
Mylan Pharmaceuticals 2
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Sponsor Type

Sponsor Type for Alendronate Sodium
Sponsor Trials
Industry 17
Other 11
NIH 3
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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Dow
Daiichi Sankyo
Queensland Health
Accenture
Cipla
Medtronic
Johnson and Johnson
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