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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR ADVIL MIGRAINE LIQUI-GELS

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Clinical Trials for Advil Migraine Liqui-gels

Trial ID Title Status Sponsor Phase Summary
NCT00004654 Phase III Randomized, Placebo-Controlled, Crossover Study of Soy Protein Isolate for Hereditary Hemorrhagic Telangiectasia Completed Yale University Phase 3 OBJECTIVES: I. Evaluate migraine prophylaxis with soy protein isolate in patients with hereditary hemorrhagic telangiectasia. II. Assess whether soy protein isolate reduces the frequency and severity of epistaxis and gastrointestinal bleeding in these patients.
NCT00004654 Phase III Randomized, Placebo-Controlled, Crossover Study of Soy Protein Isolate for Hereditary Hemorrhagic Telangiectasia Completed National Center for Research Resources (NCRR) Phase 3 OBJECTIVES: I. Evaluate migraine prophylaxis with soy protein isolate in patients with hereditary hemorrhagic telangiectasia. II. Assess whether soy protein isolate reduces the frequency and severity of epistaxis and gastrointestinal bleeding in these patients.
NCT00055484 A Study to Measure the Safety and Effectiveness of Zonisamide in Subjects With Migraine Headache Completed Elan Pharmaceuticals Phase 2 The purpose of this study is to determine if zonisamide is effective as a preventative medication for individuals with migraine headache.
NCT00069355 Propranolol for the Treatment of Acute Stress Disorder Completed National Institute of Mental Health (NIMH) Phase 2 This 10-week study will examine whether propranolol, a medication that blocks the activity of the stress hormones adrenaline and noradrenaline, can relieve acute stress disorder (ASD) and symptoms from persisting long-term. ASD is a condition that some people develop soon after exposure to trauma. They may be anxious, depressed, have trouble sleeping, startle easily, have difficulties concentrating, and feel as though the event is happening again. Propranolol has been used for many years to treat high blood pressure and heart disease, and has been found useful in treating anxiety states such as social phobia and migraine. Men and women between 18 and 65 years of age who were recently exposed to trauma (between 1 and 3 weeks of evaluation in this study) may be eligible for this study. Candidates must be diagnosed with ASD and must have been mentally healthy before the traumatic event. They will be screened for the study with a medical and psychiatric interview, physical examination, electrocardiogram (EKG), and blood and urine tests. Participants will be evaluated with the following procedures: - Neuropsychological tests using pen-and-paper and computer tests to evaluate cognitive function, particularly memory, learning, attention and concentration, and vocabulary and naming. - Emotion-related performance tasks to determine if the study medication can weaken emotionally arousing information by blocking the activity of adrenaline and noradrenaline. Subjects perform emotion-related and neutral tasks, such as looking at pictures with neutral, pleasant, or unpleasant content, both before and after treatment with the study medication (see below). - Traumatic script exposure: Subjects recount the traumatic event that caused them to develop ASD. The description is summarized, recorded, and played back to the subject. During the playback, physiological responses, such as heart rate and skin conductance (sweating), are recorded using electrodes taped to the hand and chest. - Fear conditioning to evaluate the response to an unpleasant stimulus: Several mild electrical shocks are delivered to the wrists while the subject looks at colored squares. Heart rate and skin conductance are measured. - Magnetic resonance imaging (MRI) to examine brain structure. The subject lies on a table that is moved into the MRI scanner (a narrow cylinder containing a strong magnetic field) and must remain still during the actual scanning. Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process. After the evaluation, participants are randomly assigned to receive either propranolol or placebo (a look-alike pill with no active ingredient) for 8 weeks During this time they are seen by a doctor once a week for 4 weeks and then once every other week for the rest of the study. At the end of the 8-week treatment period, participants undergo the same evaluation they had before beginning treatment (see above). The decision to continue treatment will then be decided based on the individual's clinical condition and whether he or she received propranolol or placebo.
NCT00075010 Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes Completed Eisai Inc. Phase 1/Phase 2 Valproic acid is a medication that is currently used in the prevention of seizures, bipolar disorder, and migraine headaches. Researchers hope that it may improve the effects of decitabine. Decitabine is a chemotherapy drug with known activity in leukemia and myelodysplastic syndromes.
NCT00075010 Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes Completed M.D. Anderson Cancer Center Phase 1/Phase 2 Valproic acid is a medication that is currently used in the prevention of seizures, bipolar disorder, and migraine headaches. Researchers hope that it may improve the effects of decitabine. Decitabine is a chemotherapy drug with known activity in leukemia and myelodysplastic syndromes.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Advil Migraine Liqui-gels

Condition Name

Condition Name for Advil Migraine Liqui-gels
Intervention Trials
Migraine 209
Migraine Disorders 68
Migraine Headache 43
Headache 30
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Condition MeSH

Condition MeSH for Advil Migraine Liqui-gels
Intervention Trials
Migraine Disorders 436
Headache 159
Migraine with Aura 34
Migraine without Aura 32
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Clinical Trial Locations for Advil Migraine Liqui-gels

Trials by Country

Trials by Country for Advil Migraine Liqui-gels
Location Trials
Canada 49
Denmark 47
Japan 44
United Kingdom 43
Germany 39
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Trials by US State

Trials by US State for Advil Migraine Liqui-gels
Location Trials
California 109
New York 105
Florida 94
Missouri 93
Texas 86
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Clinical Trial Progress for Advil Migraine Liqui-gels

Clinical Trial Phase

Clinical Trial Phase for Advil Migraine Liqui-gels
Clinical Trial Phase Trials
Phase 4 117
Phase 3 153
Phase 2/Phase 3 21
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Clinical Trial Status

Clinical Trial Status for Advil Migraine Liqui-gels
Clinical Trial Phase Trials
Completed 318
Recruiting 89
Not yet recruiting 42
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Clinical Trial Sponsors for Advil Migraine Liqui-gels

Sponsor Name

Sponsor Name for Advil Migraine Liqui-gels
Sponsor Trials
GlaxoSmithKline 38
Merck Sharp & Dohme Corp. 37
Danish Headache Center 23
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Sponsor Type

Sponsor Type for Advil Migraine Liqui-gels
Sponsor Trials
Other 361
Industry 341
NIH 14
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Serving hundreds of leading biopharmaceutical companies globally:

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