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Last Updated: February 24, 2020

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CLINICAL TRIALS PROFILE FOR ADVIL ALLERGY AND CONGESTION RELIEF

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505(b)(2) Clinical Trials for Advil Allergy And Congestion Relief

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
OTC NCT00487032 Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation Completed Brian J Lipworth Phase 4 2008-05-01 The investigators wish to evaluate the onset of tolerance to nasal decongestants like oxymetazoline (available over the counter) and the mechanism of tolerance particularly with differential effects on alpha 1 and alpha 2 adrenoreceptors on the nose. The investigators will 'tease' out by using an alpha 1 blocker called Prazosin. The investigators hypothesize that alpha 1 receptors mediate arterial constriction and this will be captured by measuring nasal blood flow. The investigators also hypothesize that alpha 2 receptors mediate venous sinusoid constriction and this the investigators will capture by airflow parameters like Peak Nasal Inspiratory Flow, Rhinomanometry, Oscillometric indices etc.
OTC NCT01448057 Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu Completed Novartis Phase 3 2013-07-01 The study is a clinical evaluation of an over the counter (OTC) combination product containing paracetamol (500 mg), dimethindene maleate (1 mg), phenylephrine hydrochloride (10 mg) compared to paracetamol (500 mg) alone in the treatment of nasal congestion, rhinorrhea, sneezing and other symptoms due to upper respiratory tract infection (URTI).
New Formulation NCT03339726 Randomized, Double-blind, Placebo-Controlled, Efficacy Study of a New Formulation of Phenylephrine HCL in the Common Cold Not yet recruiting Johnson & Johnson Consumer Inc. (J&JCI) Phase 2 2017-11-15 This will be a randomized, double-blind, placebo controlled, parallel-group Phase 2 study to evaluate the efficacy of a new formulation of phenylephrine HCl and a currently marketed phenylephrine HCl for relief of nasal congestion in subjects with naturally occurring cold symptoms.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Advil Allergy And Congestion Relief

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00115622 Study In Adults And Adolescents With Seasonal Allergic Rhinitis Completed GlaxoSmithKline Phase 3 2004-12-01 The purpose of the study is to compare the efficacy and safety of an investigational nasal spray compared with placebo nasal spray in the treatment of seasonal allergic rhinitis. Allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. The focus of this study, seasonal allergic rhinitis (SAR), is one type of allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. Commonly referred to as "hay fever", it is characterized by sneezing, nasal congestion and pruritus, rhinorrhea, and pruritic, watery, red eyes.
NCT00118729 Study In Adolescent And Adult Subjects 12 Years Of Age And Older With Seasonal Allergic Rhinitis To Assess Onset of Action Completed GlaxoSmithKline Phase 3 2005-04-01 Allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. The focus of this study, seasonal allergic rhinitis (SAR), is one type of allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. Commonly referred to as "hay fever", it is characterized by sneezing, nasal congestion and pruritus, rhinorrhea, and pruritic, watery, red eyes. The purpose of this study is to evaluate the onset of action of an investigational nasal spray, GW685698X aqueous nasal spray, versus vehicle placebo nasal spray in the treatment of seasonal allergic rhinitis caused by ragweed following a single dose of treatment in controlled pollen concentrations in an allergen challenge chamber.
NCT00124137 Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD) Completed CHF Solutions N/A 2004-04-01 The purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the hospital and improve the patient's breathing.
NCT00197262 Once-Daily Investigational Nasal Spray In Adults And Adolescents With Seasonal Allergic Rhinitis (SAR) Completed GlaxoSmithKline Phase 3 2005-08-01 Allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. The focus of this study, seasonal allergic rhinitis (SAR), is one type of allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. Commonly referred to as (hay fever), it is characterized by sneezing, nasal congestion and pruritus, rhinorrhea, and pruritic, watery, red eyes. The primary objective of this study is to compare the efficacy and safety of GW685698X 100mcg once daily (QD) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with seasonal allergic rhinitis (SAR) caused by ragweed pollen.
NCT00224523 Long Term Safety Of GW685698X Via Nasal Biopsy Completed GlaxoSmithKline Phase 3 2005-09-01 Long term safety (52 weeks) of GW685698X on the nasal mucosa via nasal biopsy with an active control group (Nasonex®) and a healthy volunteers control group in subjects 18 years old with perennial allergic rhinitis . Allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. Perennial allergic rhinitis is triggered by house dust mites, animal dander, etc., possibly causing symptoms year-round including nasal congestion, rhinorrhea and/or nasal itching.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Advil Allergy And Congestion Relief

Condition Name

Condition Name for Advil Allergy And Congestion Relief
Intervention Trials
Heart Failure 21
Allergic Rhinitis 19
Seasonal Allergic Rhinitis 14
Rhinitis, Allergic, Seasonal 10
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Condition MeSH

Condition MeSH for Advil Allergy And Congestion Relief
Intervention Trials
Rhinitis 66
Rhinitis, Allergic 56
Heart Failure 52
Rhinitis, Allergic, Seasonal 31
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Clinical Trial Locations for Advil Allergy And Congestion Relief

Trials by Country

Trials by Country for Advil Allergy And Congestion Relief
Location Trials
United States 266
Italy 16
Canada 15
Spain 14
France 11
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Trials by US State

Trials by US State for Advil Allergy And Congestion Relief
Location Trials
Texas 21
Ohio 13
Missouri 12
California 12
Illinois 11
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Clinical Trial Progress for Advil Allergy And Congestion Relief

Clinical Trial Phase

Clinical Trial Phase for Advil Allergy And Congestion Relief
Clinical Trial Phase Trials
Phase 4 56
Phase 3 82
Phase 2/Phase 3 6
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Clinical Trial Status

Clinical Trial Status for Advil Allergy And Congestion Relief
Clinical Trial Phase Trials
Completed 112
Recruiting 38
Not yet recruiting 23
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Clinical Trial Sponsors for Advil Allergy And Congestion Relief

Sponsor Name

Sponsor Name for Advil Allergy And Congestion Relief
Sponsor Trials
GlaxoSmithKline 17
Merck Sharp & Dohme Corp. 15
Bayer 7
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Sponsor Type

Sponsor Type for Advil Allergy And Congestion Relief
Sponsor Trials
Other 196
Industry 127
NIH 6
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