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Last Updated: November 17, 2019

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR ACYCLOVIR

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All Clinical Trials for Acyclovir

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000138 Herpetic Eye Disease Study (HEDS) I Unknown status National Eye Institute (NEI) Phase 3 1989-05-01 To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis in conjunction with topical trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex stromal keratitis in patients receiving concomitant topical corticosteroids and trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex iridocyclitis in conjunction with treatment with topical corticosteroids and trifluridine.
NCT00000139 Herpetic Eye Disease Study (HEDS) II Completed National Eye Institute (NEI) Phase 3 1992-10-01 To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV) ulcerations of the corneal epithelium prevents progression to the blinding complications of stromal keratitis and iridocyclitis. To determine the efficacy of low-dose oral acyclovir in preventing recurrent HSV eye infection in patients with previous episodes of herpetic eye disease. To determine the role of external factors (such as ultraviolet light or corneal trauma) and behavioral factors (such as life stress) on the induction of ocular recurrences of HSV eye infections and disease.
NCT00000635 Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine Completed Glaxo Wellcome N/A 1969-12-31 To determine the safety, effectiveness, and toxicity of topical (local) trifluridine in treating mucocutaneous (at the nasal, oral, vaginal, and anal openings) Herpes simplex virus ( HSV ) disease that has shown resistance to acyclovir in HIV-infected patients. HSV infection in patients with AIDS is often associated with skin sores and frequent recurrences. Treatment with the drug acyclovir results in healing for most patients, but repeated treatment sometimes results in resistance of the virus to acyclovir. Thus, when this happens, other treatments need to be used. Trifluridine is an antiviral drug that is used for the treatment of Herpes infections that occur in the eye. This study attempts to determine if trifluridine is useful for treating HSV sores that have not healed after treatment with acyclovir.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Acyclovir

Condition Name

Condition Name for Acyclovir
Intervention Trials
HIV Infections 27
Herpes Simplex 23
Herpes Labialis 9
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Condition MeSH

Condition MeSH for Acyclovir
Intervention Trials
Herpes Simplex 38
HIV Infections 30
Infection 21
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Clinical Trial Locations for Acyclovir

Trials by Country

Trials by Country for Acyclovir
Location Trials
United States 339
Canada 11
Israel 4
Brazil 3
United Kingdom 3
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Trials by US State

Trials by US State for Acyclovir
Location Trials
Texas 29
California 28
New York 22
Illinois 21
Washington 18
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Clinical Trial Progress for Acyclovir

Clinical Trial Phase

Clinical Trial Phase for Acyclovir
Clinical Trial Phase Trials
Phase 4 12
Phase 3 26
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Acyclovir
Clinical Trial Phase Trials
Completed 74
Unknown status 8
Not yet recruiting 6
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Clinical Trial Sponsors for Acyclovir

Sponsor Name

Sponsor Name for Acyclovir
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 20
Glaxo Wellcome 9
University of Washington 9
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Sponsor Type

Sponsor Type for Acyclovir
Sponsor Trials
Other 78
Industry 46
NIH 43
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