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Generated: February 20, 2019

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CLINICAL TRIALS PROFILE FOR ACALABRUTINIB

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Clinical Trials for Acalabrutinib

Trial ID Title Status Sponsor Phase Summary
NCT02029443 ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (Btk) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia Active, not recruiting Acerta Pharma BV Phase 1/Phase 2 This study is evaluating the safety and efficacy of a new Bruton tyrosine kinase (Btk) inhibitor, acalabrutinib, for the treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
NCT02157324 Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia Active, not recruiting Acerta Pharma BV Phase 1 This study is evaluating the safety and efficacy of the combined use of acalabrutinib and ACP-319, for the treatment of chronic lymphocytic leukemia (CLL)
NCT02180711 An Open-label, Phase 1b Study of Acalabrutinib Alone or in Combination With Rituximab in Subjects With Follicular Lymphoma Active, not recruiting Acerta Pharma, LLC Phase 1 To characterize the safety profile of acalabrutinib alone or in combination with rituximab in subjects with relapsed,refractory,or treatment naive Follicular Lymphoma (FL)
NCT02180711 An Open-label, Phase 1b Study of Acalabrutinib Alone or in Combination With Rituximab in Subjects With Follicular Lymphoma Active, not recruiting Acerta Pharma BV Phase 1 To characterize the safety profile of acalabrutinib alone or in combination with rituximab in subjects with relapsed,refractory,or treatment naive Follicular Lymphoma (FL)
NCT02211014 An Open-Label, Phase 1b Study of Acalabrutinib With and Without Dexamethasone in Subjects With Multiple Myeloma Active, not recruiting Acerta Pharma, LLC Phase 1 To characterize the safety profile of acalabrutinib with and without dexamethasone in subjects with relapsed or refractory Multiple Myeloma (MM)
NCT02211014 An Open-Label, Phase 1b Study of Acalabrutinib With and Without Dexamethasone in Subjects With Multiple Myeloma Active, not recruiting Acerta Pharma BV Phase 1 To characterize the safety profile of acalabrutinib with and without dexamethasone in subjects with relapsed or refractory Multiple Myeloma (MM)
NCT02213926 An Open-label, Phase 2 Study of ACP-196 (Acalabrutinib) in Subjects With Mantle Cell Lymphoma Active, not recruiting Acerta Pharma BV Phase 2 The purpose of this study is to characterize the safety and efficacy profile of ACP-196 (acalabrutinib) in subjects with relapsed or refractory Mantle Cell Lymphoma (MCL).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Acalabrutinib

Condition Name

Condition Name for Acalabrutinib
Intervention Trials
Chronic Lymphocytic Leukemia 11
Small Lymphocytic Lymphoma 4
Prolymphocytic Leukemia 2
DLBCL 2
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Condition MeSH

Condition MeSH for Acalabrutinib
Intervention Trials
Leukemia, Lymphocytic, Chronic, B-Cell 14
Leukemia, Lymphoid 14
Leukemia 11
Lymphoma 11
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Clinical Trial Locations for Acalabrutinib

Trials by Country

Trials by Country for Acalabrutinib
Location Trials
United States 81
United Kingdom 7
Italy 2
Belgium 1
Poland 1
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Trials by US State

Trials by US State for Acalabrutinib
Location Trials
Ohio 9
Washington 7
Texas 6
New York 6
Maryland 6
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Clinical Trial Progress for Acalabrutinib

Clinical Trial Phase

Clinical Trial Phase for Acalabrutinib
Clinical Trial Phase Trials
Phase 3 5
Phase 2 12
Phase 1/Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Acalabrutinib
Clinical Trial Phase Trials
Recruiting 12
Active, not recruiting 9
Not yet recruiting 8
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Clinical Trial Sponsors for Acalabrutinib

Sponsor Name

Sponsor Name for Acalabrutinib
Sponsor Trials
Acerta Pharma BV 23
Merck Sharp & Dohme Corp. 4
Acerta Pharma, LLC 2
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Sponsor Type

Sponsor Type for Acalabrutinib
Sponsor Trials
Industry 30
Other 10
NIH 3
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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Farmers Insurance
Johnson and Johnson
Merck
Deloitte
UBS
Daiichi Sankyo
Teva
Cerilliant

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