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Last Updated: April 20, 2024

CLINICAL TRIALS PROFILE FOR APREPITANT


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505(b)(2) Clinical Trials for APREPITANT

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Indication NCT00090155 ↗ 2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-090)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 2003-09-26 The purpose of this study is to assess the safety and efficacy of 2 doses of an approved drug for a new indication in the prevention of postoperative nausea and vomiting in patients receiving general anesthesia for open abdominal surgery requiring overnight hospital stay.
New Indication NCT00090246 ↗ 2 Doses of an Approved Drug Being Studied for a New Indication for the Prevention of Postoperative Nausea and Vomiting (0869-091) Completed Merck Sharp & Dohme Corp. Phase 3 2004-05-13 The purpose of this study is to assess the safety and efficacy of 2 doses of an approved drug for a new indication in the prevention of postoperative nausea and vomiting in patients receiving general anesthesia for open abdominal surgery requiring overnight hospital stay.
New Combination NCT01012336 ↗ Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin Completed Merck Sharp & Dohme Corp. Phase 2 2010-05-01 The current recommended guideline for patients receiving moderately emetogenic chemotherapy (MEC) is the combination of a 5-HT3 receptor antagonist and corticosteroid. Incidence of chemotherapy induced nausea and vomiting (CINV) is approximately 50% in patients receiving MEC. An incidence rate of 25-38% for delayed emesis and 55-60% for delayed nausea has been observed. Hence, there is clearly a need for more effective prevention of CINV in patients receiving MEC, especially in women with ovarian carcinoma who are particularly susceptible to these symptoms. Therefore the investigators designed a study with the objective to evaluate if new combination (Aprepitant/Ramosetron/Dexamethasone) may improve actual CINV control in ovarian carcinoma patients treated with taxane/carboplatin.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for APREPITANT

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00034983 ↗ Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 2001-10-29 A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression
NCT00035048 ↗ Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 2001-11-21 A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.
NCT00035282 ↗ Treatment of Patients With Major Depressive Disorder With MK0869 (0869-060)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 2001-09-01 A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for APREPITANT

Condition Name

Condition Name for APREPITANT
Intervention Trials
Vomiting 28
Nausea 26
Chemotherapy-induced Nausea and Vomiting 24
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Condition MeSH

Condition MeSH for APREPITANT
Intervention Trials
Vomiting 103
Nausea 86
Postoperative Nausea and Vomiting 32
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Clinical Trial Locations for APREPITANT

Trials by Country

Trials by Country for APREPITANT
Location Trials
United States 132
Italy 19
China 14
Korea, Republic of 7
Germany 6
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Trials by US State

Trials by US State for APREPITANT
Location Trials
Pennsylvania 13
North Carolina 9
New York 9
California 9
Texas 8
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Clinical Trial Progress for APREPITANT

Clinical Trial Phase

Clinical Trial Phase for APREPITANT
Clinical Trial Phase Trials
Phase 4 35
Phase 3 43
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for APREPITANT
Clinical Trial Phase Trials
Completed 108
Unknown status 26
Terminated 14
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Clinical Trial Sponsors for APREPITANT

Sponsor Name

Sponsor Name for APREPITANT
Sponsor Trials
Merck Sharp & Dohme Corp. 52
National Cancer Institute (NCI) 11
National Institute on Drug Abuse (NIDA) 6
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Sponsor Type

Sponsor Type for APREPITANT
Sponsor Trials
Other 184
Industry 71
NIH 21
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