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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR AMITRIPTYLINE HYDROCHLORIDE


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All Clinical Trials for AMITRIPTYLINE HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000428 ↗ Combining N-of-1 Trials to Assess Fibromyalgia Treatments Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 4 2000-09-01 This study will compare the effectiveness of combination therapy with the drugs amitriptyline and fluoxetine (AM+FL) and amitriptyline (AM) alone in the treatment of people with fibromyalgia. Doctors will treat each study participant with both AM + FL and AM alone for 6 weeks at a time. The study uses a method that combines results from treatment of individual patients to assess overall treatment effectiveness and help individual patients and their physicians with their treatment decisions. This study will also help compare the results of community-based studies (studies involving private doctors) and studies based at clinical research centers.
NCT00000428 ↗ Combining N-of-1 Trials to Assess Fibromyalgia Treatments Completed Tufts Medical Center Phase 4 2000-09-01 This study will compare the effectiveness of combination therapy with the drugs amitriptyline and fluoxetine (AM+FL) and amitriptyline (AM) alone in the treatment of people with fibromyalgia. Doctors will treat each study participant with both AM + FL and AM alone for 6 weeks at a time. The study uses a method that combines results from treatment of individual patients to assess overall treatment effectiveness and help individual patients and their physicians with their treatment decisions. This study will also help compare the results of community-based studies (studies involving private doctors) and studies based at clinical research centers.
NCT00000793 ↗ A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection Completed Boehringer Ingelheim Phase 2 1969-12-31 To assess the efficacy, safety, and tolerability of amitriptyline hydrochloride versus mexiletine hydrochloride in reducing pain intensity in patients with HIV-related painful peripheral neuropathy. No large-scale controlled clinical trials of symptomatic therapy for painful HIV-related neuropathy have been attempted. Both amitriptyline and mexiletine have been useful in the management of painful neuropathies; however, both are associated with certain toxicities. In this comparative study of amitriptyline and mexiletine, benztropine mesylate also will be included as an active placebo to mimic the side effects of the study drugs.
NCT00000793 ↗ A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 1969-12-31 To assess the efficacy, safety, and tolerability of amitriptyline hydrochloride versus mexiletine hydrochloride in reducing pain intensity in patients with HIV-related painful peripheral neuropathy. No large-scale controlled clinical trials of symptomatic therapy for painful HIV-related neuropathy have been attempted. Both amitriptyline and mexiletine have been useful in the management of painful neuropathies; however, both are associated with certain toxicities. In this comparative study of amitriptyline and mexiletine, benztropine mesylate also will be included as an active placebo to mimic the side effects of the study drugs.
NCT00000817 ↗ The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1994-11-01 To evaluate the separate and combined efficacy of a standardized acupuncture regimen and amitriptyline on the relief of pain due to peripheral neuropathy and on the quality of life of HIV-infected patients. Both amitriptyline, an antidepressant, and acupuncture, a Chinese medical approach that uses needles to relieve pain, have been used successfully to reduce pain in some people. It is not known how effectively these approaches relieve or reduce pain in patients with peripheral neuropathy secondary to HIV infection.
NCT00006427 ↗ Chronic Pain After Amputation Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 4 1996-08-01 This trial will test the effectiveness of amitriptyline in relieving chronic pain of adults that have had an amputation
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for AMITRIPTYLINE HYDROCHLORIDE

Condition Name

Condition Name for AMITRIPTYLINE HYDROCHLORIDE
Intervention Trials
Migraine 12
Fibromyalgia 11
Pain 9
Headache 7
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Condition MeSH

Condition MeSH for AMITRIPTYLINE HYDROCHLORIDE
Intervention Trials
Migraine Disorders 16
Depression 14
Neuralgia 13
Fibromyalgia 12
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Clinical Trial Locations for AMITRIPTYLINE HYDROCHLORIDE

Trials by Country

Trials by Country for AMITRIPTYLINE HYDROCHLORIDE
Location Trials
United States 162
Canada 12
Germany 12
Brazil 12
France 5
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Trials by US State

Trials by US State for AMITRIPTYLINE HYDROCHLORIDE
Location Trials
Washington 9
New York 9
Ohio 9
California 7
Pennsylvania 7
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Clinical Trial Progress for AMITRIPTYLINE HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for AMITRIPTYLINE HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 4 28
Phase 3 24
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for AMITRIPTYLINE HYDROCHLORIDE
Clinical Trial Phase Trials
Completed 65
Unknown status 16
Recruiting 14
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Clinical Trial Sponsors for AMITRIPTYLINE HYDROCHLORIDE

Sponsor Name

Sponsor Name for AMITRIPTYLINE HYDROCHLORIDE
Sponsor Trials
Children's Hospital Medical Center, Cincinnati 4
Federal University of São Paulo 4
University of Washington 3
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Sponsor Type

Sponsor Type for AMITRIPTYLINE HYDROCHLORIDE
Sponsor Trials
Other 150
Industry 26
NIH 20
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