Phase II Double-Blind, Placebo-Controlled Study of the Reinforcing Effects of Alprazolam in Patients With Anxiety
Completed
University of Texas
Phase 2
1997-03-01
OBJECTIVES: I. Determine whether the benzodiazepine alprazolam reinforces self-medication
behavior in anxious patients with varying histories of using other drugs.
II. Establish outpatient methods for the study of self-medication and drug reinforcement in
patients vulnerable to prescription drug abuse or dependence.
III. Evaluate the influence of alcohol and other non-prescription drug use as determinants of
vulnerability in these patients.
IV. Identify personality, attitudinal, or other variables that might predict different
patterns of self-medication.
V. Assess the effects of cognitive-behavioral therapy on alprazolam self-medication.
Phase II Double-Blind, Placebo-Controlled Study of the Reinforcing Effects of Alprazolam in Patients With Anxiety
Completed
National Institute on Drug Abuse (NIDA)
Phase 2
1997-03-01
OBJECTIVES: I. Determine whether the benzodiazepine alprazolam reinforces self-medication
behavior in anxious patients with varying histories of using other drugs.
II. Establish outpatient methods for the study of self-medication and drug reinforcement in
patients vulnerable to prescription drug abuse or dependence.
III. Evaluate the influence of alcohol and other non-prescription drug use as determinants of
vulnerability in these patients.
IV. Identify personality, attitudinal, or other variables that might predict different
patterns of self-medication.
V. Assess the effects of cognitive-behavioral therapy on alprazolam self-medication.
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