Combination Chemotherapy With or Without High Dose Cyclophosphamide and Recombinant Interferon Alfa-2b in Treating Patients With Previously Untreated Stage I-III Multiple Myeloma
Completed
National Cancer Institute (NCI)
Phase 3
1994-07-01
This randomized phase III clinical trial studies combination chemotherapy with high dose
cyclophosphamide and recombinant interferon alfa-2b to see how well it works compared to
combination chemotherapy alone in treating patients with previously untreated stage I-III
multiple myeloma. Drugs used in chemotherapy, such as vincristine sulfate, carmustine,
melphalan, cyclophosphamide, and prednisone, work in different ways to stop the growth of
cancer cells, either by killing the cells or by stopping them from dividing. Recombinant
interferon alfa-2b may interfere with the growth of cancer cells. It is not yet know whether
giving combination chemotherapy with or without alternating high-dose cyclophosphamide and
recombinant interferon alfa-2b is more effective in treating multiple myeloma.
Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors
Completed
National Cancer Institute (NCI)
Phase 2
1994-09-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
that they stop growing or die. bone marrow transplantation and peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more
tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by
bone marrow transplantation and/or peripheral stem cell transplantation in treating patients
who have recurrent medulloblastoma or CNS germ cell tumors.
Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors
Completed
Children's Oncology Group
Phase 2
1994-09-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
that they stop growing or die. bone marrow transplantation and peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more
tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by
bone marrow transplantation and/or peripheral stem cell transplantation in treating patients
who have recurrent medulloblastoma or CNS germ cell tumors.
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