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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Baxter
Daiichi Sankyo
US Department of Justice
Johnson and Johnson
AstraZeneca
Teva
Boehringer Ingelheim
Mallinckrodt

Generated: April 19, 2018

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CLINICAL TRIALS PROFILE FOR ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

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Clinical Trials for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

Trial ID Title Status Sponsor Phase Summary
NCT00000138 Herpetic Eye Disease Study (HEDS) I Unknown status National Eye Institute (NEI) Phase 3 To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis in conjunction with topical trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex stromal keratitis in patients receiving concomitant topical corticosteroids and trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex iridocyclitis in conjunction with treatment with topical corticosteroids and trifluridine.
NCT00000139 Herpetic Eye Disease Study (HEDS) II Completed National Eye Institute (NEI) Phase 3 To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV) ulcerations of the corneal epithelium prevents progression to the blinding complications of stromal keratitis and iridocyclitis. To determine the efficacy of low-dose oral acyclovir in preventing recurrent HSV eye infection in patients with previous episodes of herpetic eye disease. To determine the role of external factors (such as ultraviolet light or corneal trauma) and behavioral factors (such as life stress) on the induction of ocular recurrences of HSV eye infections and disease.
NCT00000635 Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine Completed Glaxo Wellcome N/A To determine the safety, effectiveness, and toxicity of topical (local) trifluridine in treating mucocutaneous (at the nasal, oral, vaginal, and anal openings) Herpes simplex virus ( HSV ) disease that has shown resistance to acyclovir in HIV-infected patients. HSV infection in patients with AIDS is often associated with skin sores and frequent recurrences. Treatment with the drug acyclovir results in healing for most patients, but repeated treatment sometimes results in resistance of the virus to acyclovir. Thus, when this happens, other treatments need to be used. Trifluridine is an antiviral drug that is used for the treatment of Herpes infections that occur in the eye. This study attempts to determine if trifluridine is useful for treating HSV sores that have not healed after treatment with acyclovir.
NCT00000635 Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A To determine the safety, effectiveness, and toxicity of topical (local) trifluridine in treating mucocutaneous (at the nasal, oral, vaginal, and anal openings) Herpes simplex virus ( HSV ) disease that has shown resistance to acyclovir in HIV-infected patients. HSV infection in patients with AIDS is often associated with skin sores and frequent recurrences. Treatment with the drug acyclovir results in healing for most patients, but repeated treatment sometimes results in resistance of the virus to acyclovir. Thus, when this happens, other treatments need to be used. Trifluridine is an antiviral drug that is used for the treatment of Herpes infections that occur in the eye. This study attempts to determine if trifluridine is useful for treating HSV sores that have not healed after treatment with acyclovir.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

Condition Name

Condition Name for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Intervention Trials
HIV Infections 27
Herpes Simplex 23
Ocular Hypertension 21
Glaucoma 11
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Condition MeSH

Condition MeSH for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Intervention Trials
Herpes Simplex 36
HIV Infections 30
Glaucoma 25
Infection 23
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Clinical Trial Locations for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

Trials by Country

Trials by Country for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Location Trials
United States 452
Canada 16
United Kingdom 9
Austria 8
Italy 7
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Trials by US State

Trials by US State for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Location Trials
Texas 43
California 38
New York 27
Illinois 26
Florida 24
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Clinical Trial Progress for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

Clinical Trial Phase

Clinical Trial Phase for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Clinical Trial Phase Trials
Phase 4 62
Phase 3 47
Phase 2/Phase 3 11
[disabled in preview] 34
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Clinical Trial Status

Clinical Trial Status for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Clinical Trial Phase Trials
Completed 143
Recruiting 32
Unknown status 20
[disabled in preview] 16
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Clinical Trial Sponsors for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE

Sponsor Name

Sponsor Name for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 20
University of Washington 10
M.D. Anderson Cancer Center 9
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Sponsor Type

Sponsor Type for ACYCLOVIR IN SODIUM CHLORIDE 0.9% PRESERVATIVE FREE
Sponsor Trials
Other 187
Industry 103
NIH 52
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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
Argus Health
Cantor Fitzgerald
Johnson and Johnson
Deloitte
Fish and Richardson
US Department of Justice
Boehringer Ingelheim
Queensland Health

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