Bulk Pharmaceutical API Sources for METAHYDRIN

Bulk Pharmaceutical API Sources for METAHYDRIN

Vendor	Vendor Homepage	Vendor Sku	API Url
Sigma-Aldrich		T1016_SIGMA
NovoSeek		5560
MP Biomedicals		190020
TCI (Tokyo Chemical Industry)		T1318

Bulk Active Pharmaceutical Ingredient (API) Sources for: METAHYDRIN

Last updated: July 29, 2025

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Introduction

Metahydrin, also known as 4,4'-methylenebis(2-chloroaniline) (MBOCA), is a crucial active pharmaceutical ingredient (API) predominantly used in the manufacturing of polyurethanes, elastic fibers, and rubber chemicals. Its significance in industrial applications underscores the importance of securing reliable bulk API sources. This article explores the global landscape of bulk MBOCA suppliers, examining manufacturing concentrations, key geographic hubs, regulatory considerations, and the current market dynamics crucial for stakeholders in the pharmaceutical and chemical sectors.

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Overview of Metahydrin (MBOCA)

Metahydrin (CAS Number: 101-77-9) is an aromatic diamine primarily employed as a stabilizer in polyurethane foams and elastomers. It possesses chemical stability and compatibility conducive to polymerization processes, making its supply chain particularly sensitive to quality and regulatory compliance. Due to its toxicological profile and strict regulations—particularly concerning occupational safety and environmental impact—selecting reputable suppliers with proven safety standards is paramount.

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Global API Manufacturing Landscape for MBOCA

Major Production Regions

The bulk production of MBOCA is concentrated in key chemical manufacturing hubs, with China and India emerging as dominant players due to their expansive chemical industries and cost advantages.

• China: As the world's largest chemical producer, China accounts for approximately 60-70% of global MBOCA manufacturing capacity. Major chemical conglomerates, such as Zhejiang Longsheng Group and Linyi Chengda Chemical Co., Ltd., are notable producers that supply both local and international markets. Chinese manufacturers benefit from significant R&D investments and a robust supplier network.

• India: India is also a significant API manufacturing hub, with companies like Gujarat Alkalies and Chemicals Limited and other specialty chemical producers supplying MBOCA to regional and global customers. The Indian industry benefits from government initiatives aimed at enhancing chemical manufacturing infrastructure and quality standards.

• Europe and North America: These regions host a smaller share of MBOCA production, primarily serving markets with strict regulatory environments requiring high purity and quality standards. European and North American manufacturers tend to focus on specialty-grade API manufacturing, emphasizing compliance with Good Manufacturing Practices (GMP).

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Key API Suppliers and Distributors

The supply of MBOCA is heavily reliant on integrated chemical companies with capabilities ranging from raw material synthesis to final API production. Top suppliers are characterized by their adherence to international safety and quality standards:

• Zhejiang Longsheng Group (China): A leading chemical producer with a strong presence in specialty chemicals, including APIs for polyurethane applications. Their MBOCA manufacturing facilities are compliant with international standards, making them a preferred supplier globally.

• Linyi Chengda Chemical Co., Ltd. (China): Focused on aromatic amines, including MBOCA, with large-scale production capacity and competitive pricing.

• Gujarat Alkalies and Chemicals Limited (India): Offers a range of aromatic amines, including MBOCA, with GMP certification and a focus on environmental compliance.

• Mistral Chemicals Ltd. (UK): A specialty chemical distributor sourcing MBOCA from Asian manufacturers and providing logistics and compliance support for international clients.

• Other Notable Suppliers: Companies such as Yantai Jereh Chemical Industry Co., Ltd. (China) and Indian specialty chemical firms supply MBOCA in tailored quantities, often serving niche markets.

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Supply Chain and Regulatory Considerations

Given MBOCA's toxicological profile, supply chain integrity and regulatory adherence are critical considerations:

• Regulatory Environment: Authorities such as the US EPA, European Chemicals Agency (ECHA), and China's Ministry of Ecology and Environment oversee MBOCA production and use, demanding compliance with strict safety standards, environmental controls, and registration processes (e.g., REACH registration in Europe).

• Quality and Certification: Buyers prioritize suppliers offering ISO certifications, GMP compliance, and comprehensive analytical data. The demand for high-purity API limits the number of qualified producers.

• Supply Chain Risks: Disruptions due to geopolitical tensions, environmental regulations, or safety incidents can affect MBOCA availability, underscoring the importance of diversified sourcing strategies.

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Market Dynamics and Trends

• Growth Drivers: The expanding polyurethane and automotive industries, where MBOCA acts as a stabilizer, drive demand. Additionally, regulatory tightening in Western markets prompts manufacturers to seek compliant, high-quality sources.

• Pricing Trends: Global supply chain constraints and raw material costs influence API pricing, with Chinese manufacturers historically offering the most competitive prices. However, quality differentiation often aligns with premium pricing for GMP-compliant sources.

• Emerging Suppliers: Efforts to develop greener manufacturing processes and alternative raw materials are ongoing, potentially reshaping the supply landscape over the next decade.

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Conclusion

Securing a reliable source of bulk MBOCA API necessitates careful evaluation of geographic origins, manufacturing standards, regulatory compliance, and supply chain resilience. Chinese and Indian producers dominate the market, driven by scale and cost advantages, but European and North American entities remain vital for high-quality, compliant supply chains. As industry regulations tighten and demand grows, partnerships with reputable suppliers capable of meeting international safety standards will be crucial for pharmaceutical and polymer manufacturers seeking consistent MBOCA supply.

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Key Takeaways

• The Asian chemical industry, particularly China and India, leads in MBOCA production, offering competitive pricing and substantial capacity.
• Regulatory compliance and high-quality certifications are vital for sourcing MBOCA, especially for pharmaceutical applications.
• Diversifying suppliers reduces risks associated with geopolitical, environmental, and regulatory disruptions.
• Industry trends indicate growing demand from the polyurethane sector, with sustainable manufacturing practices potentially influencing future supply sources.
• Close cooperation with suppliers and ongoing vigilance of regulatory developments enhance supply chain stability and product quality assurance.

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FAQs

1. What are the primary geographic regions for bulk MBOCA API supply?
China and India dominate MBOCA production, with China accounting for approximately 60-70% of global capacity. Europe and North America provide smaller but high-quality supplies catering to stringent regulatory environments.

2. How does regulatory compliance impact MBOCA sourcing?
Regulations such as REACH (Europe), TSCA (U.S.), and Chinese environmental laws demand rigorous safety, environmental controls, and documentation, making compliance crucial in selecting suppliers capable of meeting these standards.

3. What are the main applications driving demand for MBOCA?
MBOCA is primarily used as a stabilizer in polyurethane foams and elastomers, as well as in rubber chemicals and adhesives, with the polyurethane industry being the largest consumer segment.

4. What risks should buyers consider when sourcing MBOCA?
Risks include supply chain disruptions, regulatory non-compliance, quality variations, and environmental or safety incidents at manufacturing facilities. Diversification and thorough supplier verification are recommended strategies.

5. Are there sustainable or eco-friendly alternatives to MBOCA?
Research into green manufacturing processes and alternative raw materials is ongoing, aiming to reduce environmental impact. However, currently, MBOCA remains essential for many industrial applications, and sustainable innovations are in developmental stages.

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References

1. [1] ChemSpider, "Metahydrin (MBOCA) CAS 101-77-9," accessed 2023.
2. [2] European Chemicals Agency, "REACH registration dossiers for aromatic amines," 2023.
3. [3] GlobalTrade.net, "Chemical Suppliers Directory," 2023.
4. [4] Industry Reports, "Polyurethane Market Trends," 2022.
5. [5] U.S. EPA, "Chemical Safety Data Sheets," 2023.