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Last Updated: December 15, 2025

Biologic Drugs With Physiological Effect: Increased Coagulation Activity

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Biologic Drugs With Physiological Effect: Increased Coagulation Activity

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Baxter Healthcare Corporation	TISSEEL	fibrin sealant (tisseel)	For Injection	103980	2000-02-07	⤷ Get Started Free	⤷ Get Started Free
Octapharma Pharmazeutika Produktionsges.m.b.h.	WILATE	von willebrand factor/coagulation factor viii complex (human)	For Injection	125251	2010-12-20	⤷ Get Started Free	⤷ Get Started Free
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	Frozen	125266	2008-03-19	⤷ Get Started Free	⤷ Get Started Free
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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