Last Updated: November 8, 2026

Biologic Drugs With Physiological Effect: Increased Coagulation Activity

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Biologic Drugs With Physiological Effect: Increased Coagulation Activity

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Baxter Healthcare Corporation	TISSEEL	fibrin sealant (tisseel)	For Injection	103980	2000-02-07	⤷ Start Trial	⤷ Start Trial
Octapharma Pharmazeutika Produktionsges.m.b.h.	WILATE	von willebrand factor/coagulation factor viii complex (human)	For Injection	125251	2010-12-20	⤷ Start Trial	⤷ Start Trial
Octapharma Pharmazeutika Produktionsges.m.b.h.	WILATE	von willebrand factor/coagulation factor viii complex (human)	For Injection	125251	2010-12-20	10,065,997	⤷ Start Trial
Octapharma Pharmazeutika Produktionsges.m.b.h.	WILATE	von willebrand factor/coagulation factor viii complex (human)	For Injection	125251	2010-12-20	10,632,192	⤷ Start Trial
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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