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Last Updated: December 18, 2025

Patent: 9,481,728

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Summary for Patent: 9,481,728

Title:	Compositions and methods for treatment of cancer
Abstract:	The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
Inventor(s):	Carl H. June, Bruce L. Levine, David L. Porter, Michael D. Kalos, Michael C. Milone
Assignee:	University of Pennsylvania Penn
Application Number:	US14/984,371
Patent Claims:	see list of patent claims

Details for Patent 9,481,728

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novartis Pharmaceuticals Corporation	KYMRIAH	tisagenlecleucel	Injection	125646	August 30, 2017	⤷ Get Started Free	2035-12-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,481,728

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Country	Patent Number	Estimated Expiration
South Africa	201304470	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2012079000	⤷ Get Started Free
United States of America	9540445	⤷ Get Started Free
United States of America	9518123	⤷ Get Started Free
United States of America	9499629	⤷ Get Started Free
United States of America	9464140	⤷ Get Started Free
United States of America	9328156	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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