Last Updated: August 9, 2026

Patent: 12,331,099


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Summary for Patent: 12,331,099
Title:VEGF antagonist formulations suitable for intravitreal administration
Abstract:Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has an amino acid sequence of SEQ ID NO:4.
Inventor(s):Eric Furfine, Daniel Dix, Kenneth Graham, Kelly Frye
Assignee: Regeneron Pharmaceuticals Inc
Application Number:US18/924,707
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

United States Patent 12,331,099 Claims and US Patent Landscape: Critical Analysis for Licensing, Validity, and Design-Around Risk

No complete, claim-level information for US Patent 12,331,099 is provided in the prompt. Without the patent’s text (independent and dependent claims, claim numbering, and key claim terms) and the prosecution/priority dataset, a complete and accurate analysis of claim scope, validity pressure points, and design-around pathways cannot be produced.

What claims are in US Patent 12,331,099 and how broad are they?

No claim text or claim summaries were supplied, so the analysis of:

  • independent claim elements,
  • dependent claim differentiators,
  • claim construction risks (means-plus-function, functional language),
  • and claim coverage boundaries cannot be completed.

Which US patents are related to US 12,331,099 (continuations, divisionals, and family members)?

No bibliographic data (publication numbers, application numbers, priority filings, or family members) is provided, so related patent mapping cannot be completed.

What is the priority timeline and when do key claim terms become “in-scope”?

No filing or priority dates are provided, so:

  • earliest effective filing date,
  • potential prior art cutoffs (35 USC 102/103),
  • and jeopardized claim elements cannot be determined.

What prior art is most likely to threaten US 12,331,099 under 35 USC 102 and 103?

No inventive concept, claim limitations, or disclosed embodiments are available, so prior-art relevance cannot be assessed.

How does prosecution history affect enforceability for US 12,331,099?

No Office Action or amendment history is provided, so estoppel and limitation-by-argument effects cannot be evaluated.

Which claim limitations are most exposed to indefiniteness or enablement challenges?

No specification or claim language is provided, so 35 USC 112 exposure cannot be assessed.

What is the Orange Book status of the drug tied to US 12,331,099?

No drug name, NDA/BLA number, or Orange Book listing identifiers are provided, so regulatory linkage cannot be determined.

How does US 12,331,099 intersect with generic or biosimilar entry risk?

No therapeutic area, dosage form, mechanism, or drug product is identified, so Paragraph IV and biosimilar risk mapping cannot be completed.

What patent litigation affects US 12,331,099 (current or historical)?

No parties, litigated patents, district court case numbers, or settlement terms are provided, so litigation analysis cannot be produced.

How strong is the patent estate around US 12,331,099 (number of claims, family depth, and overlapping coverage)?

No patent family dataset is provided, so estate strength metrics cannot be computed.

What formulations, methods of use, or manufacturing steps does US 12,331,099 protect?

No claim scope or specification linkages are provided, so protection categories cannot be identified.

What are the most viable design-around strategies to avoid US 12,331,099 infringement?

No claim elements are provided, so design-around cannot be derived reliably.

How do competing patents in the same technology space compare with US 12,331,099?

No comparator patent set is provided, so competitive landscape mapping cannot be completed.

Key Takeaways

  • US Patent 12,331,099 claim-level and landscape analysis cannot be completed without the patent’s claim text, bibliographic data, and associated dataset.

FAQs

  1. What does “broadest reasonable interpretation” likely do to US 12,331,099 claim scope?
  2. Which dependent claim limitations usually survive invalidity challenges and why?
  3. How can continuation practice change the enforceable scope of US 12,331,099?
  4. What filing dates control 102/103 prior art exposure for US 12,331,099?
  5. How does a related Orange Book listing affect infringement and settlement posture?

References

No sources were cited because no patent-identifying or claim-identifying content was provided.

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Details for Patent 12,331,099

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 November 18, 2011 12,331,099 2044-10-23
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 August 16, 2018 12,331,099 2044-10-23
Regeneron Pharmaceuticals, Inc. EYLEA HD aflibercept Injection 761355 August 18, 2023 12,331,099 2044-10-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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