Patent: 10,588,983
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Summary for Patent: 10,588,983
| Title: | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| Abstract: | The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. |
| Inventor(s): | Bookbinder; Louis H. (San Diego, CA), Kundu; Anirban (Georgetown, KY), Frost; Gregory I. (Palm Beach, FL) |
| Assignee: | Halozyme, Inc. (San Diego, CA) |
| Application Number: | 15/904,247 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,588,983
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Bausch & Lomb Incorporated | VITRASE | hyaluronidase | Injection | 021640 | 05/05/2004 | ⤷ Try a Trial | 2025-02-23 |
| Bausch & Lomb Incorporated | VITRASE | hyaluronidase | Injection | 021640 | 12/02/2004 | ⤷ Try a Trial | 2025-02-23 |
| Amphastar Pharmaceuticals, Inc. | AMPHADASE | hyaluronidase | Injection | 021665 | 10/26/2004 | ⤷ Try a Trial | 2025-02-23 |
| Akorn, Inc. | HYDASE | hyaluronidase | Injection | 021716 | 10/25/2005 | ⤷ Try a Trial | 2025-02-23 |
| Octapharma Pharmazeutika Produktionsges.m.b.h. | OCTAGAM | immune globulin intravenous (human) | Injection | 125062 | 05/21/2004 | ⤷ Try a Trial | 2025-02-23 |
| Octapharma Pharmazeutika Produktionsges.m.b.h. | OCTAGAM | immune globulin intravenous (human) | Injection | 125062 | 03/26/2007 | ⤷ Try a Trial | 2025-02-23 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
