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Last Updated: July 11, 2020

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Patent: 9,315,811

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Summary for Patent: 9,315,811
Title:Methods for modulating kallikrein (KLKB1) expression
Abstract: Disclosed herein are methods for decreasing kallikrein and treating or preventing inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to kallikrein include hereditary angioedema (HAE). Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for developing an inflammatory condition, such as, hereditary angioedema.
Inventor(s): Bhattacharjee; Gourab (San Diego, CA), Revenko; Alexey (San Diego, CA), MacLeod; Robert A. (San Diego, CA)
Assignee: Ionis Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:14/124,630
Patent Claims:see list of patent claims

Details for Patent 9,315,811

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Csl Behring Gmbh BERINERT human c1-esterase inhibitor KIT 125287 1 2011-12-22   Start Trial Ionis Pharmaceuticals, Inc. (Carlsbad, CA) 2031-06-10 search
Dyax Corp. KALBITOR ecallantide INJECTABLE; INJECTION 125277 001 2009-12-01   Start Trial Ionis Pharmaceuticals, Inc. (Carlsbad, CA) 2031-06-10 RX Orphan search
Viropharma Biologics, Inc. CINRYZE human c1-esterase inhibitor INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 125267 1 2008-12-01   Start Trial Ionis Pharmaceuticals, Inc. (Carlsbad, CA) 2031-06-10 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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