Patent: 8,703,801

Summary for Patent: 8,703,801

Title:	Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications
Abstract:	New chiral and achiral oxy-substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.
Inventor(s):	Nair; Vasu (Athens, GA), Okello; Maurice O. (Athens, GA), Nishonov; Abdumalik A. (Boulder, CO), Mishra; Sanjaykumar (Pune, IN)
Assignee:	University of Georgia Research Foundation, Inc. (Athens, GA)
Application Number:	13/513,448
Patent Claims:	see list of patent claims

Details for Patent 8,703,801

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	06/23/1987		2029-12-07
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	10/16/1986		2029-12-07
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	02/04/1999		2029-12-07
Emd Serono, Inc.	SAIZEN	somatropin	For Injection	019764	10/08/1996		2029-12-07
Emd Serono, Inc.	SAIZEN	somatropin	For Injection	019764	08/29/2000		2029-12-07
Emd Serono, Inc.	SAIZEN	somatropin	For Injection	019764	01/16/2007		2029-12-07