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Last Updated: September 22, 2020

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Patent: 8,551,942

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Summary for Patent: 8,551,942
Title:Lyophilized anti-fungal compositions
Abstract: A lyophilized anti-fungal composition comprises (A) caspofungin, or a pharmaceutically acceptable salt thereof, in an effective amount; (B) one or more non-reducing sugars having a glass transition temperature T.sub.g(s) of at least about 90.degree. C.; and (C) an acetate buffer in an amount effective to provide a pH in a range of from about 5 to about 7; wherein the weight ratio of the one or more non-reducing sugars to caspofungin is in a range of from about 1.1:1 to about 10:1; the composition has a moisture content of about 0.8 wt. % or less; and the composition has a glass transition temperature T.sub.g(c) of at least about 55.degree. C. The lyophilized composition has good storage stability at temperatures up to and including room temperature. The composition can be reconstituted for use in preventing or treating fungal infections.
Inventor(s): Mittal; Sachin (Bridgewater, NJ), Jahansouz; Hossain (Burlingame, CA), Sottivirat; Sutthilug (Lansdale, PA)
Assignee: Merck Sharp & Dohme, Corp. (Rahway, NJ)
Application Number:13/628,592
Patent Claims:see list of patent claims

Details for Patent 8,551,942

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Merck Sharp & Dohme, Corp. (Rahway, NJ) 2027-06-26 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Merck Sharp & Dohme, Corp. (Rahway, NJ) 2027-06-26 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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