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Last Updated: March 28, 2024

Patent: 8,399,006


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Summary for Patent: 8,399,006
Title:Posterior segment drug delivery
Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
Inventor(s): de Juan, Jr.; Eugene (San Francisco, CA), Alster; Yair (Palo Alto, CA), Chamow; Steven M. (San Mateo, CA), Farinas; Kathleen Cogan (Los Altos, CA), Gifford, III; Hanson S. (Woodside, CA), Macfarlane; K. Angela (Woodside, CA), Reich; Cary J. (Los Gatos, CA), Barrett; Michael (Cupertino, CA), Campbell; Randolph E. (Redwood City, CA), George; Robert (San Jose, CA), Sutton; Douglas (Pacifica, CA)
Assignee: Forsight Vision4, Inc. (Menlo Park, CA)
Application Number:12/696,678
Patent Claims:see list of patent claims

Details for Patent 8,399,006

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Emd Serono, Inc. PERGONAL menotropins For Injection 017646 08/22/1975 ⤷  Try a Trial 2029-01-29
Emd Serono, Inc. PERGONAL menotropins For Injection 017646 05/20/1985 ⤷  Try a Trial 2029-01-29
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 06/23/1987 ⤷  Try a Trial 2029-01-29
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 10/16/1986 ⤷  Try a Trial 2029-01-29
Eli Lilly And Company HUMATROPE somatropin For Injection 019640 02/04/1999 ⤷  Try a Trial 2029-01-29
Emd Serono, Inc. SAIZEN somatropin For Injection 019764 10/08/1996 ⤷  Try a Trial 2029-01-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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