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Last Updated: June 4, 2023

Patent: 8,013,113

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Summary for Patent: 8,013,113
Title:FRET protease assays for clostridial toxins
Abstract: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.
Inventor(s): Steward; Lance E. (Irvine, CA), Fernandez-Salas; Ester (Fullerton, CA), Aoki; Kei Roger (Coto de Caza, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:12/620,434
Patent Claims:see list of patent claims

Details for Patent 8,013,113

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Solstice Neurosciences, Llc MYOBLOC rimabotulinumtoxinb Injection 103846 12/08/2000 ⤷  Try a Trial 2021-08-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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