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Last Updated: October 26, 2020

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Patent: 8,013,113

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Summary for Patent: 8,013,113
Title:FRET protease assays for clostridial toxins
Abstract: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.
Inventor(s): Steward; Lance E. (Irvine, CA), Fernandez-Salas; Ester (Fullerton, CA), Aoki; Kei Roger (Coto de Caza, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:12/620,434
Patent Claims:see list of patent claims

Details for Patent 8,013,113

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Elan Pharm MYOBLOC botulinum toxin type b VIAL 103846 001 2000-12-08   Start Trial Allergan, Inc. (Irvine, CA) 2021-08-28 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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