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Last Updated: March 29, 2024

Patent: 7,189,827


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Summary for Patent: 7,189,827
Title:Modified peptides as therapeutic agents
Abstract: The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising: a) selecting at least one peptide that modulates the activity of a protein of interest; and b) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide. Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide is preferably selected by phage display, E. coli display, ribosome display, RNA-peptide screening, or chemical-peptide screening.
Inventor(s): Feige; Ulrich (Newbury Park, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Application Number:10/632,388
Patent Claims:see list of patent claims

Details for Patent 7,189,827

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Amgen, Inc. NPLATE romiplostim For Injection 125268 08/22/2008 ⤷  Try a Trial 2018-10-23
Amgen, Inc. NPLATE romiplostim For Injection 125268 10/17/2019 ⤷  Try a Trial 2018-10-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 7,189,827

Country Patent Number Estimated Expiration
South Africa 200102753 ⤷  Try a Trial
Yugoslavia 25901 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 0183525 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 0024782 ⤷  Try a Trial
United States of America 7488590 ⤷  Try a Trial
United States of America 7186810 ⤷  Try a Trial
United States of America 7169905 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration

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