Last Updated: November 9, 2026

Patent: 6,887,462

Summary for Patent: 6,887,462

Title:	HSA-free formulations of interferon-beta
Abstract:	Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
Inventor(s):	Bret A. Shirley, Susan Babuka, Bao-Lu Chen, Maninder Hora, Minna Choe, Melanie Tellers
Assignee:	GlaxoSmithKline Biologicals SA
Application Number:	US10/035,397
Patent Claims:	see list of patent claims

Details for Patent 6,887,462

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	March 7, 2002	⤷ Start Trial	2021-10-25
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	December 17, 2004	⤷ Start Trial	2021-10-25
Emd Serono, Inc.	REBIF	interferon beta-1a	Injection	103780	December 21, 2012	⤷ Start Trial	2021-10-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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