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Last Updated: November 27, 2021

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Patent: 6,815,184

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Summary for Patent: 6,815,184
Title: Expression of biologically active polypeptide in duckweed
Abstract:Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium.
Inventor(s): Stomp; Anne-Marie (Moncure, NC), Dickey; Lynn (Cary, NC), Gasdaska; John (Carrboro, NC)
Assignee: Biolex, Inc. (Pittsboro, NC)
Application Number:09/915,873
Patent Claims:see list of patent claims

Details for Patent 6,815,184

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2020-07-31
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2020-07-31
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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