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Last Updated: October 1, 2023

Patent: 6,815,184

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Summary for Patent: 6,815,184

Title:	Expression of biologically active polypeptide in duckweed
Abstract:	Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium.
Inventor(s):	Stomp; Anne-Marie (Moncure, NC), Dickey; Lynn (Cary, NC), Gasdaska; John (Carrboro, NC)
Assignee:	Biolex, Inc. (Pittsboro, NC)
Application Number:	09/915,873
Patent Claims:	see list of patent claims

Details for Patent 6,815,184

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2020-07-31
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2020-07-31
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2020-07-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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