Last Updated: September 25, 2026

Patent: 6,783,965


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Summary for Patent: 6,783,965
Title:Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
Abstract:A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
Inventor(s):Merry R. Sherman, Mark G. P. Saifer, L. David Williams
Assignee: Duke University , Horizon Therapeutics USA Inc
Application Number:US09/501,730
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

United States Patent 6,783,965 Claims Analysis and U.S. Patent Landscape (Critical Freedom-to-Operate View)

What does US Patent 6,783,965 claim, and how broad are the independent claims?

US Patent 6,783,965 is not identifiable from the information provided in this thread with sufficient specificity to extract the claim set, independent claim scope, or enable a reliable validity/strength assessment. A complete and accurate claims analysis requires the patent’s authoritative full text (claims and specification), which is not available here.

Claim-scope mapping that would normally be performed

A proper landscape requires, at minimum:

  • Independent claim list with element-by-element breakdown
  • Definitions used in the claim language (including “comprising” vs. “consisting,” ranges, functional limitations, and dependent claim narrowing)
  • Claim construction-critical terms (e.g., “effective,” “therapeutically,” “substantially,” “about,” “comprising,” “at least,” “tunable,” “targeting”)
  • Priority chain and whether claims are supported across the specification
  • Whether the patent is a composition, method-of-use, device, formulation, or process patent
  • Whether the independent claims are likely to be anticipated by single references or obvious over combinations

No such claim text is available in this context, so a complete response cannot be produced without introducing inaccuracies.


What patents are likely to be related to US 6,783,965 in the U.S. (family members, continuations, continuations-in-part)?

A correct related-patent analysis depends on:

  • The patent’s inventors/assignee
  • The priority application(s)
  • The claim subject matter class
  • The family tree (continuations, CIPs, divisionals)

These are not provided. Without the patent bibliographic record and family data, any list of related patents would be speculative.


When does US Patent 6,783,965 expire, and what exclusivity effects exist in the U.S.?

Expiration depends on:

  • Filing date, priority date, and whether maintenance fees were paid
  • Terminal disclaimers
  • Patent term adjustments (PTA) and adjustments attributable to USPTO delays
  • Whether the patent is tied to an FDA-approved drug with regulatory exclusivities (NCE, 5-year new chemical entity, orphan drug exclusivity, pediatric exclusivity)

None of these inputs are available in this thread. A precise expiration timeline cannot be produced.


Is US Patent 6,783,965 listed in the Orange Book, and what does that imply for generic launch risk?

Orange Book listing can only be determined by the drug product(s) associated with the patent (active ingredient + dosage form). A patent number alone is not sufficient because:

  • Many patents are not Orange Book-listed even if they are therapeutic or formulation related
  • Some Orange Book-listed patents map to method-of-use or formulation patents, changing the generic risk profile

No Orange Book mapping is provided, and no Orange Book query is possible from this context.


How strong is the patent estate around US 6,783,965 (independent claim defensibility and likely invalidity vectors)?

A critical strength analysis requires:

  • The invention type (composition, method, device, process)
  • Claim breadth (coverage of subject matter and alternatives)
  • Prior art landscape around the effective filing date
  • Whether the claims are written in a way that is vulnerable to:
    • anticipation under 35 USC 102 (including AIA 102)
    • obviousness under 35 USC 103
    • indefiniteness under 35 USC 112(b)
    • written description and enablement under 35 USC 112(a)

Without the actual claims and without a prior-art record, this cannot be done without fabrication.


What prior art most threatens US Patent 6,783,965 (102/103 risk map by claim element)?

A 102/103 risk map requires:

  • The specific claim elements
  • The priority filing date
  • The technical subject matter
  • Candidate prior art categories (papers, patents, regulatory filings, product disclosures)

No claim text or subject-matter description is available in this context. A credible mapping cannot be generated.


What patent litigation or PTAB activity involves US 6,783,965, and how does it change enforcement value?

Litigation and PTAB history require:

  • Case caption(s), district court, docket numbers
  • asserted claims
  • settlement terms (if any), injunctions, and claim construction rulings
  • IPR/PGR/Ex parte reexamination outcomes and estoppel effects

No litigation/PTAB record is provided here. Without it, a “comprehensive and critical analysis” would be unsupported.


If a generic or biosimilar tried to enter, what entry barriers would US Patent 6,783,965 create?

Entry barriers depend on:

  • Whether the patent covers an Orange Book-listed method-of-use/formulation or a non-listed process claim
  • Whether the claim reads on design-around options (different routes, different excipients, different dosing regimens, different target binding, etc.)
  • Whether the patent is enforceable and not expired/invalidated

Because the patent’s subject matter is not known from the prompt, entry barrier analysis cannot be accurate.


What claim design-arounds could a competitor pursue to avoid infringement of US 6,783,965?

Design-around analysis must be claim-specific:

  • Identify literal infringement pathways vs. doctrine-of-equivalents risk
  • Determine which elements are limiting vs. optional
  • Identify claim terms that can be avoided by selecting different structures, ranges, or performance characteristics

No claims are available, so design-around guidance would be speculative.


Key Takeaways

No definitive claims or landscape facts can be stated for US Patent 6,783,965 from the information present in this thread. A comprehensive, critical analysis requires the patent’s claim text, bibliographic data, and linkage to any Orange Book listing, none of which are provided here.


FAQs

  1. How do I determine the independent claim scope of US Patent 6,783,965 from the patent record?
  2. What steps show whether US Patent 6,783,965 is enforceable in the U.S. (term, disclaimers, and maintenance fees)?
  3. How do Orange Book “drug product” mappings determine generic entry risk for a given U.S. patent number?
  4. How should claim element matching be structured for infringement analysis of method-of-use vs. formulation patents?
  5. What PTAB outcomes most strongly affect enforcement leverage for a U.S. patent asserted against generics?

References

No sources were provided or citable from this thread.

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Details for Patent 6,783,965

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Horizon Therapeutics Ireland Dac KRYSTEXXA pegloticase Injection 125293 14-Sep-10 6,783,965 2020-02-10
Horizon Therapeutics Ireland Dac KRYSTEXXA pegloticase Injection 125293 29-Aug-25 6,783,965 2020-02-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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