Last Updated: August 30, 2026

Patent: 6,258,358

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Summary for Patent: 6,258,358

Title:	Targeted immunostimulation with bispecific reagents
Abstract:	Disclosed are methods of stimulating in a subject an immune response to an antigen to which the immune response is targeted. This method includes the step of administering to the subject a binding agent which binds a surface receptor of an antigen-presenting cell, in some instances without being blocked substantially by the natural ligand for the surface receptor, and an antigen to which the immune response is targeted, in a physiologically acceptable medium to the subject. Also disclosed are molecular complexes including the binding agent coupled to an antigen.
Inventor(s):	Jean Loup Romet-Lemonne, Michael W. Fanger, Paul M. Guyre, Edmund J. Gosselin
Assignee:	Dartmouth College , Celldex Research Corp
Application Number:	US08/453,500
Patent Claims:	see list of patent claims

Details for Patent 6,258,358

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Sanofi Vaccines Canada Ltd.	ADACEL	tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed	Injection	125111	June 10, 2005	⤷ Start Trial	2018-07-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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