Last Updated: May 10, 2026

Patent: 6,828,121

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Summary for Patent: 6,828,121

Title:	Bacterial host strains
Abstract:	An E. coli strain is described that is deficient in chromosomal degP and prc encoding protease DegP and Prc, respectively, and harbors a mutant spr gene that encodes a protein that suppresses growth phenotypes exhibited by strains harboring prc mutants. Preferably, the strain comprises nucleic acid encoding a polypeptide heterologous to the strain, so that a heterologous polypeptide can be produced therefrom.
Inventor(s):	Christina Yu-Ching Chen
Assignee:	Genentech Inc
Application Number:	US10/011,125
Patent Claims:	see list of patent claims

Details for Patent 6,828,121

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	6,828,121	2021-12-07
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	August 10, 2012	6,828,121	2021-12-07
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	October 13, 2016	6,828,121	2021-12-07
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	March 20, 2018	6,828,121	2021-12-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 6,828,121

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Country	Patent Number	Estimated Expiration
South Africa	200304101	⤷ Start Trial
World Intellectual Property Organization (WIPO)	0248376	⤷ Start Trial
United States of America	2002142388	⤷ Start Trial
Russian Federation	2287574	⤷ Start Trial
Russian Federation	2003121232	⤷ Start Trial
Poland	366194	⤷ Start Trial
Poland	205897	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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