Patent: 5,904,922
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Summary for Patent: 5,904,922
Title: | Treatment with polyvalent antivenom containing immunoglobulin which is greater than 50% venom-reactive |
Abstract: | Antivenoms to snake, spider, scorpion and jelly fish venoms are produced for treatment of humans and animals, and for analytical use. Polyvalent antivenoms are produced containing immunoglobulin which is greater than fifty percent venom reactive. Purified polyvalent antivenom is derived from a first polyvalent antivenom having two or more monovalent subpopulations, and purified such that greater than fifty percent of the monovalent subpopulations are recovered by weight. The antivenoms can be horse or avian such as chicken antivenom. Chicken antivenom is obtained using a whole venom that is not glutaraldehyde pretreated, and the antivenom contains yolk immunoglobulin. Antivenoms are purified with an antigen matrix containing a single whole venom or a plurality of whole venoms covalently attached to an insoluble support such as aldehyde-activated agarose. Preferably, the whole venoms forming the plurality of whole venoms are selected from the four whole venoms of C. atrox, B. atrox, C. adamanteus and C. durissus terrificus. A combination of immobilized C. atrox and C. durissus terrificus whole venoms can substantially purify antivenom reactive with all four venoms. The antivenoms are intravenously injected to treat an envenomed mammalian subject. |
Inventor(s): | Carroll; Sean B. (Cottage Grove, WI) |
Assignee: | Ophidian Pharmaceuticals, Inc. (Madison, WI) |
Application Number: | 08/442,000 |
Patent Claims: | see list of patent claims |
Details for Patent 5,904,922
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | LACTRODECTUS MACTANS | antivenin (latrodectus mactans) | For Injection | 101062 | 02/13/1936 | ⤷ Try a Trial | 2016-05-18 |
Wyeth Pharmaceuticals Llc | MICRURUS FULVIUS | antivenin (micrurus fulvius) | For Injection | 101099 | 08/28/1967 | ⤷ Try a Trial | 2016-05-18 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |