Last Updated: May 1, 2026

Patent: 5,843,705

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Summary for Patent: 5,843,705

Title:	Transgenically produced antithrombin III
Abstract:	This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GaINAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid/N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.
Inventor(s):	DiTullio; Paul (Framingham, MA), Meade; Harry (Newton, MA), Cole; Edward S. (Mendon, MA)
Assignee:	Genzyme Transgenic Corporation (Framingham, MA)
Application Number:	08/391,743
Patent Claims:	see list of patent claims

Details for Patent 5,843,705

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	THROMBATE III	antithrombin iii (human)	For Injection	103196	December 30, 1991	5,843,705	2015-02-21
Revo Biologics, Inc.	ATRYN	antithrombin (recombinant)	For Injection	125284	February 06, 2009	5,843,705	2015-02-21
Revo Biologics, Inc.	ATRYN	antithrombin (recombinant)	For Injection	125284	April 11, 2014	5,843,705	2015-02-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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