2\'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
A compound having the formula: ##STR1## wherein, R1 represents 2\'-O-R.sub.3 -thio-R.sub.3 and/or 2\'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is independently a moiety selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
Beigelman; Leonid (Longmont, CO), Karpeisky; Alex (Boulder, CO)
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