Last Updated: May 20, 2026

Patent: 5,527,692

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Summary for Patent: 5,527,692

Title:	Methods for producing thrombin
Abstract:	Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elements: a transcriptional promoter, DNA sequence encoding a gla-domainless prothrombin, and a transcriptional terminator. Thrombin precursors produced from transformed or transfected host cells are activated either in vivo or in vitro.
Inventor(s):	Richard D. Holly, Donald C. Foster
Assignee:	International Business Machines Corp , Medicines Co
Application Number:	US08/462,261
Patent Claims:	see list of patent claims

Details for Patent 5,527,692

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Baxter Healthcare Corporation	RECOTHROM	thrombin topical (recombinant)	For Solution	125248	January 17, 2008	⤷ Start Trial	2015-06-05
Baxter Healthcare Corporation	RECOTHROM	thrombin topical (recombinant)	For Solution	125248	May 23, 2008	⤷ Start Trial	2015-06-05
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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