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Last Updated: April 25, 2024

Patent: 5,454,786

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Summary for Patent: 5,454,786

Title:	Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
Abstract:	A cartridge assembly for holding a lyophilized product, forming a disposable portion of a pen injector includes a cylindrical glass cartridge adapted to receive the product, a closure cap, a cartridge case, and a plunger mechanism. The closure cap is adapted to retain an elastomeric disc seal during lyophilization and includes diametrically opposed ledges. The closure cap and seal are adapted to cover a neck portion of the ampule, the neck portion having on its end a radially extending circumferential flange. The ledges of the closure cap and the flange of the neck portion allow the closure cap to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap aids in snapping the closure cap about the flange without crimping to retain the closure cap underneath the flange. Reconstitution of the lyophilized drug is accomplished without foaming by use of an obliquely angled connector which causes the diluent to indirectly impinge on the drug. The injection pen and cartridge assembly cooperate such that the length of travel of the plunger rod during retraction is less than the axial length of a recess in the rod tip.
Inventor(s):	Harris; Dale C. (Fairland, IN)
Assignee:	Eli Lilly and Company (Indianapolis, IN)
Application Number:	08/218,653
Patent Claims:	see list of patent claims

Details for Patent 5,454,786

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	06/23/1987	⤷ Try a Trial	2013-03-15
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	10/16/1986	⤷ Try a Trial	2013-03-15
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	02/04/1999	⤷ Try a Trial	2013-03-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,454,786

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Country	Patent Number	Estimated Expiration
Austria	179881	⤷ Try a Trial
Australia	6407294	⤷ Try a Trial
Australia	675837	⤷ Try a Trial
Brazil	9406004	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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