Last Updated: May 11, 2026

Patent: 4,364,861


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Summary for Patent: 4,364,861
Title: Blood-coagulation-promoting products and methods of preparing them
Abstract:Blood-coagulation-promoting products substantially free of thrombin are prepared from human blood plasma by contacting a human blood plasma fraction containing coagulation Factors II, VII, IX and X with an anion exchanger to adsorb the coagulation Factors, which are subsequently eluted from the anion exchanger. The eluate is treated to generate a substance having Factor VIII Inhibitor Bypassing Activity and being substantially free of thrombin, and activated Factor X.
Inventor(s): Mitra; Gautam (Kensington, CA), Coan; Michael H. (El Cerrito, CA), Wada; Shohachi (Oakland, CA)
Assignee: Cutter Laboratories, Inc. (Berkeley, CA)
Application Number:06/153,341
Patent Claims:see list of patent claims

Details for Patent 4,364,861

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Takeda Pharmaceuticals U.s.a., Inc. AUTOPLEX, FEIBA NF, FEIBA VH anti-inhibitor coagulant complex For Injection 101447 December 21, 1979 ⤷  Start Trial 2000-05-27
Takeda Pharmaceuticals U.s.a., Inc. AUTOPLEX, FEIBA NF, FEIBA VH anti-inhibitor coagulant complex For Injection 101447 July 31, 2000 ⤷  Start Trial 2000-05-27
Takeda Pharmaceuticals U.s.a., Inc. AUTOPLEX, FEIBA NF, FEIBA VH anti-inhibitor coagulant complex For Injection 101447 August 11, 2005 ⤷  Start Trial 2000-05-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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