Last Updated: November 8, 2026

Patent: 4,170,639

Summary for Patent: 4,170,639

Title:	Antihemophilic factor concentrate and its production
Abstract:	Antihemophilic factor (AHF) concentrate having enhanced potency and solubility and its process of production are provided. The process includes the steps of removing unwanted protein from an aqueous extract of antihemophilic blood plasma cryoprecipitate by mixing the aqueous extract with aluminum hydroxide at an acid pH in the cold, adjusting the purified aqueous extract to an acid pH and freeze-drying the extract, optionally removing water from the extract just before freeze-drying.
Inventor(s):	Daniel T. H. Liu, John F. Irwin, Rong-Chang Pai
Assignee:	Oesterreichisches Institut fuer Haemoderivate
Application Number:	US05/923,139
Patent Claims:	see list of patent claims

Details for Patent 4,170,639

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Csl Behring Llc	MONOCLATE, MONOCLATE-P	antihemophilic factor (human)	For Injection	103953	May 14, 2003	⤷ Start Trial	1998-07-10
Csl Behring Llc	MONOCLATE, MONOCLATE-P	antihemophilic factor (human)	For Injection	103953	March 4, 2004	⤷ Start Trial	1998-07-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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