Patent: 4,086,136
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Summary for Patent: 4,086,136
| Title: | Process for producing a peptide using a serine or thiol proteinase |
| Abstract: | A peptide having the formula wherein A and B are the same or different and each represents an amino acid residue or a peptide residue, X represents an amino protective group, Y represents a carboxyl protective group selected from the group consisting of tertiary alkoxy, and benzyloxy, benzylamino and benzhydrylamino which can be substituted with an inert substituent, is prepared by a process which comprises reacting an amino acid or peptide having an N-terminal protective group, or a salt thereof of the formula: with an amino acid or peptide having a C-terminal protective group or a salt thereof of the formula: in the presence of a thiol proteinase or serine proteinase enzyme in an aqueous solution having a pH sufficient to maintain the enzyme activity of said thiol proteinase or serine proteinase. |
| Inventor(s): | Isowa; Yoshikazu (Tokyo, JA), Ohmori; Muneki (Tokyo, JA), Kurita; Hideaki (Sagamihara, JA), Ichikawa; Tetsuya (Sagamihara, JA), Sato; Masanari (Sagamihara, JA), Mori; Kaoru (Sagamihara, JA) |
| Assignee: | (Zaidanhojin) Sagami Chemical Research Center (Tokyo, JA) |
| Application Number: | 05/732,543 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,086,136
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 11/10/1982 | ⤷ Try a Trial | 2040-04-01 |
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 08/21/1984 | ⤷ Try a Trial | 2040-04-01 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
