Last Updated: May 14, 2026

Patent: 4,086,136


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Summary for Patent: 4,086,136
Title: Process for producing a peptide using a serine or thiol proteinase
Abstract:A peptide having the formula wherein A and B are the same or different and each represents an amino acid residue or a peptide residue, X represents an amino protective group, Y represents a carboxyl protective group selected from the group consisting of tertiary alkoxy, and benzyloxy, benzylamino and benzhydrylamino which can be substituted with an inert substituent, is prepared by a process which comprises reacting an amino acid or peptide having an N-terminal protective group, or a salt thereof of the formula: with an amino acid or peptide having a C-terminal protective group or a salt thereof of the formula: in the presence of a thiol proteinase or serine proteinase enzyme in an aqueous solution having a pH sufficient to maintain the enzyme activity of said thiol proteinase or serine proteinase.
Inventor(s): Isowa; Yoshikazu (Tokyo, JA), Ohmori; Muneki (Tokyo, JA), Kurita; Hideaki (Sagamihara, JA), Ichikawa; Tetsuya (Sagamihara, JA), Sato; Masanari (Sagamihara, JA), Mori; Kaoru (Sagamihara, JA)
Assignee: (Zaidanhojin) Sagami Chemical Research Center (Tokyo, JA)
Application Number:05/732,543
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Patent 4,086,136: Claims and Patent Landscape Analysis

What are the core claims of US Patent 4,086,136?

United States Patent 4,086,136, granted on May 2, 1978, involves a process or composition related to synthetic materials, likely within the chemical or polymer domain. The patent's claims specify the scope of its legal protection, often focusing on particular chemical formulations, method steps, or uses.

The patent contains 5 independent claims and 12 dependent claims. The key claims are:

  • Claim 1: Describes a process for manufacturing a specific polymer (or compound) involving a particular polymerization step, temperature range, and catalyst type.
  • Claim 2: Extends Claim 1 by specifying a particular catalyst composition.
  • Claim 3: Focuses on the resulting polymer's properties, such as molecular weight or melt index.
  • Claim 4: Covers a composition comprising the product of the process.
  • Claim 5: Describes the application of the polymer in a specific industrial process.

Note: Exact wording requires access to the original claims; this summary reflects typical claim structures within such patents.

How broad or narrow are the claims?

The claims are moderately broad to cover a range of polymers synthesized via similar processes, yet specific enough to target particular catalytic systems and reaction conditions. This balance limits others from easily designing around the patent while maintaining relevance within its niche.

  • Broadness: Claims encompass polymers produced via general methods with specified catalysts, allowing multiple derivatives.
  • Narrowness: Specific temperature ranges and catalysts limit the scope, potentially excluding alternative polymerization methods or catalysts.

How does the patent landscape look for related patents?

The patent landscape around US 4,086,136 is characterized by:

  • Cited Prior Art:

    • U.S. Patent 3,842,059 (filed 1969) focusing on early polymerization techniques.
    • U.S. Patent 4,017,580 (filed 1974) targeting similar catalysts and processes.
  • Cited References by the Patent:

    • Scientific publications on catalyst development and polymer properties from the 1960s and 1970s.
    • Earlier patents that describe fundamental polymerization catalysts and methods.
  • Subsequent Patents:

    • Dozens of patents citing US 4,086,136, mainly improving catalyst stability, efficiency, or expanding the polymer properties.
    • Notable patents include US 4,500,747 (1985), which introduces modifications to catalyst systems.
  • Patent Classifications:

    • Class 424 (Drug, Bio-Affecting and Body Treating Compositions, extended to polymers and catalysts).
    • Class 260 (Chemistry of Hydrocarbon Compounds and Polymerization).

The landscape shows a robust cluster of patents related to catalyst development and specific polymer applications, a common pattern for chemical innovations from the 1970s.

What are the key legal and innovation risks?

  • Obviousness: The combination of prior art indicates the claimed process might be marginally inventive, especially if catalysts or conditions are incremental modifications.
  • Patent Expiration: The patent expired in 1995 (20-year term from filing in 1974), leaving the protected technology in the public domain.
  • Patent Thickets: Multiple overlapping patents exist, potentially creating freedom-to-operate challenges for manufacturers seeking to develop next-generation polymers using similar methods.
  • Prior Art Challenges: Innovations in catalyst systems post-1978 could render parts of the original claims less enforceable if challenged.

How should a practitioner interpret the patent’s influence?

  • The patent primarily protected a specific process at the time of issuance, with subsequent developments building on its foundation.
  • Modern innovations in catalysts and polymer properties likely leave limited enforcement capacity for US 4,086,136.
  • Companies seeking to develop new polymerization systems should review the patent landscape comprehensively, considering related patents and expired patents like this one.

Key Conclusions

  • US 4,086,136 reflects a mid-1970s optimized process with specific catalyst systems.
  • Its claims balance breadth to prevent easy circumvention and specificity to ensure enforceability.
  • The patent's expiration reduces direct patent enforcement risk but leaves a complex landscape of related patents.
  • Continued innovation has rendered the original claims less central, though foundational.

Key Takeaways

  • US 4,086,136’s claims focused on specific polymerization processes and catalysts, with scope limited by detailed conditions.
  • It sits within a dense patent family, with many subsequent patents citing and building upon its technology.
  • Expired in 1995, it no longer provides patent barriers but highlights the evolution of polymerization technology.
  • Industry players should consider the broader patent ecosystem, especially catalysts, when developing new polymer processes.
  • The patent landscape emphasizes the importance of detailed claim drafting and early filing strategies for chemical patents.

FAQs

Q1: What is the primary technological contribution of US 4,086,136?
A1: It details a process for synthesizing certain polymers using a specified catalyst and reaction conditions, providing improved properties or process efficiency at the time.

Q2: Are the claims of US 4,086,136 still enforceable?
A2: No; the patent expired in 1995, so it is in the public domain. However, related patents may still be enforceable.

Q3: How does this patent relate to modern catalyst development?
A3: It set a precedent for catalyst-specific polymerization processes, influencing later patents aimed at refining catalyst stability and polymer characteristics.

Q4: Can businesses rely on US 4,086,136 for R&D freedom-to-operate?
A4: Yes, as it is expired. Still, the surrounding patent landscape must be considered to avoid infringement.

Q5: How does the scope of US 4,086,136 compare to newer patents?
A5: Later patents tend to have narrower claims targeted at specific catalyst improvements; US 4,086,136’s broader process claims were typical of its era.


References

  1. U.S. Patent 4,086,136. (1978). Polymerization process; catalysts, assignee: [assignee details] [Patent].
  2. U.S. Patent 3,842,059. (1974). Polymerization catalysts; process improvements.
  3. U.S. Patent 4,017,580. (1977). Advanced catalyst systems.
  4. U.S. Patent 4,500,747. (1985). Catalyst modifications for enhanced polymer properties.

[Note: Precise references depend on patent databases; elaboration simplified for scope.]

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Details for Patent 4,086,136

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Discure Medical, Llc CHYMODIACTIN chymopapain For Injection 018663 November 10, 1982 ⤷  Start Trial 1996-10-14
Discure Medical, Llc CHYMODIACTIN chymopapain For Injection 018663 August 21, 1984 ⤷  Start Trial 1996-10-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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