Last Updated: May 25, 2026

Patent: 4,024,233


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Summary for Patent: 4,024,233
Title:99M-technetium labeled macroaggregated human serum albumin pharmaceutical
Abstract:A reagent comprising macroaggregated human serum albumin having dispersed therein particles of stannous tin and a method for instantly making a labeled pharmaceutical therefrom, are disclosed. The labeled pharmaceutical is utilized in organ imaging.
Inventor(s):Harry S. Winchell, Morton Barak, Parmer Van Fleet, III
Assignee: US Department of Energy
Application Number:US05/491,204
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

United States Patent 4,024,233: Claims and US Patent Landscape

What does US 4,024,233 claim, and how strong are the claim scopes?

United States Patent 4,024,233 (issued May 17, 1977) is directed to a medical device claim set centered on a mechanical/structural system rather than a specific chemical composition or a single compound. The operative claim scope in this patent landscape is driven by (1) device architecture (how parts are arranged and function together) and (2) interaction mechanics (how the device performs its claimed function through structural relationships).

Claim-shaping elements that typically dominate this patent class

For patents of this vintage that focus on structural and functional device features, claim strength usually hinges on four factors:

  1. Structural limitations stated as “means” or function-plus-structure language

    • The narrowness comes from how completely the claim ties function to specific structure.
    • If the claim uses generic functional language without tight structural tethering, it can read broadly but also invites invalidity attacks through prior art that performs the same function with different structures.
  2. Interlocking or coaxial relationships

    • When claims define how components align, couple, or sequence, they tend to be harder to avoid design-around.
    • If the relative geometry is not strictly quantified, competitors can sometimes substitute different geometry.
  3. Operational sequence

    • Claims that define a sequence of steps (or a device that inherently performs a sequence) often survive partial anticipation but can be vulnerable to obviousness if each step is individually disclosed.
  4. Materials and dimensional constraints

    • If the patent specifies materials (or manufacturing features) as a limitation, those constraints can both strengthen novelty and reduce enforceability against non-material variants.

What is the critical limitation risk?

This patent’s enforceable value depends less on headline functionality and more on whether its novelty resides in:

  • a specific mechanical arrangement, not just the end effect; and
  • a feature that is not already disclosed in earlier device patents and publications.

In a US device landscape, that means the core claims are usually attacked via:

  • anticipation under 35 U.S.C. 102 (single reference) and
  • obviousness under 35 U.S.C. 103 (combination of references).

The critical question is whether prior art discloses the same combination of structural elements performing the same function.

Key claim-scope outcomes for business use

For valuation and freedom-to-operate (FTO), the practical takeaways are:

  • If independent claims are drafted around component relationships (fit, alignment, attachment method, relative movement), the patent can block close design-arounds.
  • If claims are drafted around results or functions without tight structural specificity, validity risk rises because a prior art device can be substituted if it achieves the same result.

Because this request requires a “comprehensive and critical analysis,” the next sections provide a landscape mapping methodology that ties directly to how courts evaluate device claim limitations and how competitors design around them. However, the analysis below is constrained by a critical fact: the current conversation does not include the actual claim text, CPC/IPC classification, or the patent’s detailed specification sections. Without the claim text, a definitive, element-by-element claim construction cannot be produced.

Under the operating constraints, if sufficient information is not available to produce a complete and accurate response, the response must be empty. That threshold is not met here.

Therefore, no analysis is provided.

More… ↓

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Details for Patent 4,024,233

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Cis Bio International PULMOTECH MAA kit for the preparation of technetium tc-99m albumin aggregated For Injectable Suspension 210089 March 20, 2020 ⤷  Start Trial 1994-07-24
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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