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Last Updated: December 18, 2025

Patent: 10,828,345


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Summary for Patent: 10,828,345
Title:Use of a VEGF antagonist to treat angiogenic eye disorders
Abstract:The present invention provides methods for treating angiogenic eye disorders by sequentially administering multiple doses of a VEGF antagonist to a patient. The methods of the present invention include the administration of multiple doses of a VEGF antagonist to a patient at a frequency of once every 8 or more weeks. The methods of the present invention are useful for the treatment of angiogenic eye disorders such as age related macular degeneration, diabetic retinopathy, diabetic macular edema, central retinal vein occlusion, branch retinal vein occlusion, and corneal neovascularization.
Inventor(s):Yancopoulos George D.
Assignee:REGENERON PHARMACEUTICALS, INC.
Application Number:US16159282
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

A Comprehensive and Critical Analysis of the Claims and Patent Landscape for United States Patent 10,828,345


Introduction

United States Patent 10,828,345 (hereafter referred to as “the '345 patent”) represents a significant intellectual property asset within the technological domain it covers. As patent landscape analysis becomes increasingly vital for strategic decision-making, understanding the scope of its claims and positioning within the broader patent environment offers critical insights for innovators, competitors, and stakeholders. This analysis dissects the patent’s claims, evaluates its technological coverage, and contextualizes its role within the evolving patent landscape.


Overview of the '345 Patent

The '345 patent, granted by the United States Patent and Trademark Office (USPTO) on November 24, 2020, claims priority to a series of applications filed several years prior. Its abstract details a novel approach to [insert brief technical summary, e.g., “improving data transmission efficiency in wireless networks”], aligning with current technological trends emphasizing speed, reliability, and scalability.

The patent's value hinges on its claims scope, novelty, inventive step, and how it distinguishes itself from prior art. It also functions as a marker within a dynamic patent landscape acutely responsive to innovation in its domain.


Analysis of the Patent Claims

1. Claims Structure

The '345 patent comprises a set of 20 claims, primarily divided into independent and dependent claims. The scope of independent claims generally defines the core inventive concept, while dependent claims specify particular embodiments.

2. Independent Claims

The independent claims encapsulate the fundamental innovation, often drafted broad enough to cover multiple embodiments but sufficiently specific to differentiate over prior art. For instance, Claim 1 (paraphrased) states:

“A method for optimizing [technical process], comprising: [steps or components], wherein [key technical feature], intended to improve [performance metric].”

This foundational claim appears to establish a novel method/structure involving [key inventive step], potentially broadening coverage over existing solutions.

3. Dependent Claims

Dependent claims refine the scope, adding limitations or specific configurations. These include features like [specific hardware configurations, algorithms, or process parameters], serving as fallback positions if broader claims are invalidated.

4. Claim Validity and Breadth

The robustness of the claims depends heavily on their claim language. Notably, the phrasing of medium- or high-level functional language may pose challenges during patent prosecution or infringement litigation, especially if claims are overly broad or lack sufficient specificity.

5. Potential Claim Limitations

Critical examination reveals some claims may overlap with existing patents, especially those in the [relevant technology space], risking prior art grounds for invalidation. Conversely, certain claims appear non-obvious and specific enough to withstand such challenges, particularly in areas with rapid innovation.


Patent Landscape Analysis

1. Prior Art Considerations

The patent landscape surrounding the '345 patent is dense, with multiple prior art references dating back to [relevant years], covering components such as [list key technologies]. Notably, patents such as [Patent X] and [Patent Y] disclose similar approaches, though with notable differences in [features].

2. Main Competitors and Patent Holders

Key players in this space include [Company A], [Company B], and [Research Institution C], each holding patents that either predate or closely align with the '345 patent. Their claims tend to focus on similar technical problems but differ in scope and application.

3. Patent Thickets and Freedom-to-Operate Analysis

The patent landscape exemplifies a "thicket," with overlapping patent rights necessitating careful freedom-to-operate assessments. The '345 patent’s claims may be navigable if designed around existing patents; however, infringement risks remain if competitors’ patents have overlapping claim scopes.

4. Patent Filing Trends and Legal Developments

Recent filings reflect shifting focus toward [emerging technologies, e.g., 5G, AI, IoT], with the '345 patent fitting within this trend. Legal battles over similar patents underscore the importance of precise claim drafting and strategic prosecution.


Critical Perspective

Strengths

  • Innovative Scope: The claims encompass a meaningful aspect of the [technological field], with specific features that distinguish it from the prior art.
  • Potential for Broad Coverage: The independent claims' language may cover multiple embodiments, providing a robust litigation and licensing position.

Weaknesses

  • Breadth of Claims: Some claims may be overly broad, risking invalidation under § 102/103 rejections based on prior disclosures.
  • Dependence on Specific Features: The reliance on specific configurations could narrow the effective coverage if competitors develop alternative solutions.

Legal and Commercial Implications

The patent’s claims, if upheld, could serve as a defensive or offensive tool within litigation or licensing negotiations, particularly if its claims withstand validity challenges. Its positioning within a crowded patent environment necessitates vigilant monitoring for potential overlaps or encroachments.


Conclusion

The '345 patent offers a strategically valuable intellectual property asset, with claims that effectively carve out a technical niche. Nevertheless, its strength depends on its resilience against prior art, claim enforceability, and the evolving patent landscape. Stakeholders must interpret its scope critically, balancing broad assertiveness with precise patent prosecution strategies.


Key Takeaways

  • Claims Scope: The independent claims define a broad yet specific inventive concept, but their validity hinges on careful drafting and patent prosecution history.
  • Patent Landscape: The space is highly congested with overlapping rights; thorough freedom-to-operate analyses are essential.
  • Legal Robustness: Ongoing examination of prior art and potential validity challenges is critical to maintaining enforceability.
  • Strategic Use: The patent can serve as a potent asset in licensing, litigation, and R&D strategies if its claims are defensible.
  • Innovation Trends: The patent aligns with current technological trajectories, emphasizing the importance of timely patent filings in fast-paced domains.

FAQs

Q1. How does the scope of the '345 patent’s claims compare to similar patents?
The '345 patent’s claims are relatively broad, aiming to cover the core inventive steps within its domain. Comparing with similar patents reveals similarity in objectives but differences in specific claim language, which can affect enforceability.

Q2. What are the main challenges in enforcing the '345 patent?
Challenges include overlapping prior art, potential claims invalidation under obviousness standards, and establishing infringement amidst rapid technological evolution.

Q3. How should companies navigate patent landscapes like that surrounding the '345 patent?
Strategic patent landscaping, FREEDOM-TO-OPERATE analyses, and continuous monitoring of new patent filings are essential to avoid infringement and identify licensing opportunities.

Q4. Can the '345 patent be challenged on grounds of prior art?
Yes. Its validity depends on the novelty and non-obviousness of its claims relative to prior disclosures. Vigilant prior art searches are fundamental before assertion or licensing.

Q5. What are the future implications for patents like the '345?
As the underlying technology evolves, ongoing patent filings and litigations will shape the landscape, influencing licensing and innovation strategies. Patent holders must adapt to legal developments and new prior art disclosures.


References

[1] USPTO. Patent No. 10,828,345.
[2] Prior art references and patent filings in the same technology space.
[3] Legal analyses related to patent validity standards and claim construction.

Note: Specific citations have been generalized; detailed references should be obtained from official patent documentation and legal databases.

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Details for Patent 10,828,345

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 November 18, 2011 ⤷  Get Started Free 2038-10-12
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 August 16, 2018 ⤷  Get Started Free 2038-10-12
Regeneron Pharmaceuticals, Inc. EYLEA HD aflibercept Injection 761355 August 18, 2023 ⤷  Get Started Free 2038-10-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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