Patent: 10,751,399
✉ Email this page to a colleague
Summary for Patent: 10,751,399
| Title: | Chimeric antigen receptors that bind to SSEA4 and uses thereof |
| Abstract: | An isolated nucleic acid that contains a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3. The polypeptide of SEQ ID NO: 3 specifically binds to stage-specific embryonic antigen 4 (SSEA4). Also disclosed is a recombinant cell comprising the isolated nucleic acid described above, a viral vector containing the above isolated nucleic acid, and an isolated polypeptide including the sequence of SEQ ID NO: 3. Provided as well is a chimeric antigen receptor (CAR) that includes a single chain Fv having the sequence of SEQ ID NO: 3 and specifically binding to SSEA4. Moreover, a method is disclosed for treating a tumor by transducing in vitro the T cells of a subject having a tumor expressing SSEA4 with a vector that encodes the CAR, expanding the transduced T cells, and infusing the expanded transduced T cells into the subject, whereby an anti-tumor T cell response is raised. |
| Inventor(s): | Lan Bo Chen |
| Assignee: | Cho Pharma Usa Inc |
| Application Number: | US15/926,382 |
| Patent Claims: | see list of patent claims |
| Patent landscape, scope, and claims summary: |
More… ↓ |
Details for Patent 10,751,399
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Sanofi-aventis U.s. Llc | ZALTRAP | ziv-aflibercept | Injection | 125418 | August 03, 2012 | ⤷ Start Trial | 2038-03-20 |
| Pfizer Inc. | ABRYSVO | respiratory syncytial virus vaccine | Injection | 125769 | May 31, 2023 | ⤷ Start Trial | 2038-03-20 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 10,751,399
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| Australia | 2019239730 | ⤷ Start Trial |
| Brazil | 112020015723 | ⤷ Start Trial |
| Canada | 3078304 | ⤷ Start Trial |
| >Country | >Patent Number | >Estimated Expiration |
