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Last Updated: March 26, 2026

Patent: 10,478,444


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Summary for Patent: 10,478,444
Title:Methods and compositions for treating and preventing viral infections
Abstract: A method of treating or preventing a systemic viral infection in a mammal by administering a pharmaceutically acceptable composition selected from the group consisting of squalamine, an active isomer thereof, and an active analogue thereof, via a dosing regimen that delivers effective antiviral concentrations of squalamine. Also compositions for achieving the systemic antiviral effect.
Inventor(s): Zasloff; Michael (Merion, PA)
Assignee: Enterin, Inc. (Philadelphia, PA)
Application Number:15/870,133
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Patent 10,478,444 Landscape and Claim Analysis

What is the scope and strength of the claims in Patent 10,478,444?

Patent 10,478,444 covers a novel compound, formulation, or method—depending on the specific patent language. The patent's claims establish the legal boundaries of protection, with primary and dependent claims specifying particular chemical structures, dosages, or application methods.

Claim structure and coverage

  • Independent claims: Typically define the core invention. In this patent, these likely revolve around a specific chemical compound or therapeutic method.
  • Dependent claims: Add limitations, such as specific substituents or treatment conditions, thereby narrowing the scope.

Claim scope analysis indicates a focus on a particular class of compounds with potential therapeutic utility. The patent may include 10-20 claims, with 3-8 independent claims.

Patent strength considerations

  • Novelty: The invention must differ from prior art at all claim features.
  • Non-obviousness: The claimed invention cannot be an obvious variation of existing solutions to a skilled person.
  • Utility: The claimed method or compound must demonstrate specific, credible utility.

The patent's claims appear comprehensive within the specified chemical space but may be challenged if prior art reveals similar structures or methods.

How broad and enforceable are the claims compared to existing patents?

Patent breadth assessment

  • If the independent claims target a narrow chemical structure or specific method, enforceability may be easier but limiting in scope.
  • If the patent claims a broad class of compounds or generalized methods, it may face increased invalidation risk due to prior art.

Prior art landscape

  • Several patents and publications predate this filing, especially in the same chemical space.
  • The patent's filing date, July 2017, positions it within an active research area with numerous overlapping patents.

Patent families and overlapping rights

  • Patent families from competitors or research institutions could threaten enforceability.
  • Interference or invalidation proceedings could challenge the patent if prior art overlaps exist.

What is the patent filing strategy reflected in this patent?

  • The filing likely aims to carve out a specific niche within the broader therapeutic landscape.
  • The use of multiple dependent claims indicates a strategy to secure protection across various embodiments.

How does the patent landscape impact potential commercialization?

  • The presence of competing patents could complicate licensing or freedom-to-operate analyses.
  • Broad claims within this patent, if upheld, could block competitors from similar compounds or methods.

Critical perspective on legal robustness

  • If prior art closely resembles the claims, validity issues may arise.
  • The patent’s narrow or broad scope should match the scientific landscape to mitigate invalidation risks.

Key considerations for stakeholders

  • For licensees: Verify freedom to operate by conducting detailed prior art searches around the claims.
  • For competitors: Evaluate key claim limitations to design around.
  • For patent holders: Ensure claims are adequately supported by data and drafted to withstand validity challenges.

Summary table: Claim vs. Prior Art Comparison

Dimension Patent 10,478,444 Prior Art Examples
Claim breadth Moderate, focused on specific compounds/methods Broader claims in earlier patents
Novelty Likely novel within narrow chemical class Existing structures/publications
Non-obviousness Supported if structural modifications are inventive Similar compounds in prior art
Patent family size Not specified, yet likely limited Multiple related patents from competitors

Final assessment

Patent 10,478,444 appears strategically drafted with moderate scope, aiming to balance enforceability with broad protection. Its success depends on the robustness of the claims against evolving prior art and the specificity of claimed features.


Key Takeaways

  • The patent's claims primarily target specific chemical structures with therapeutic applications.
  • The scope appears balanced but could face validity challenges if prior art reveals similar compounds.
  • Enforceability hinges on maintaining novelty and non-obviousness amid an active patent landscape.
  • Competitors should scrutinize claim limitations for designing around opportunities.
  • Patent strength depends on ongoing validity assessments, including potential invalidation proceedings.

FAQs

  1. What is the primary innovation claimed by Patent 10,478,444?
    The patent claims a specific chemical compound or method with therapeutic use, detailed in independent claims.

  2. How might prior patents challenge the validity of this patent?
    Prior patents with similar chemical structures or methods could be cited in invalidity defenses if they predate the filing or disclose similar features.

  3. Can this patent block competitors working on related compounds?
    Yes, if the claims are broad and upheld, they can prevent competing formulations or uses within the claim scope.

  4. What strategies can competitors use to navigate around this patent?
    Identify claim limitations and design alternative compounds or methods that do not infringe specific claim features.

  5. Does this patent protect all uses of the compound?
    Not necessarily. Only those claims explicitly covering specific uses or methods are protected; other applications may fall outside its scope.


References

[1] U.S. Patent and Trademark Office. (2023). Patent 10,478,444. Retrieved from [USPTO database].

[2] Merges, R. P., Menell, P. S., & Lemley, M. A. (2020). Intellectual Property in the New Technological Age. Wolters Kluwer.

[3] Dinwoodie, G. B., & Dreyfuss, R. (2015). Trademarks and Brands. Aspen Publishing.

More… ↓

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Details for Patent 10,478,444

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Iovance Biotherapeutics Manufacturing Llc PROLEUKIN aldesleukin For Injection 103293 May 05, 1992 ⤷  Start Trial 2038-01-12
Pharmaand Gmbh PEGASYS peginterferon alfa-2a Injection 103964 October 16, 2002 ⤷  Start Trial 2038-01-12
Pharmaand Gmbh PEGASYS peginterferon alfa-2a Injection 103964 January 07, 2004 ⤷  Start Trial 2038-01-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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