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Last Updated: December 3, 2021

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Patent: 10,280,414

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Summary for Patent: 10,280,414
Title:Stabilized .alpha.-galactosidase and uses thereof
Abstract: Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
Inventor(s): Shulman; Avidor (Rakefet, IL), Ruderfer; Ilya (Carmiel, IL), Ben-Moshe; Tehila (Koranit, IL), Shekhter; Talia (Petach-Tikva, IL), Azulay; Yaniv (Akko, IL), Kizhner; Tali (Atzmon-Segev, IL), Shaaltiel; Yoseph (Timrat, IL)
Assignee: Protalix Ltd. (Carmiel, IL)
Application Number:15/636,753
Patent Claims:see list of patent claims

Details for Patent 10,280,414

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation FABRAZYME agalsidase beta For Injection 103979 2003-04-24 ⤷  Try it Free 2029-11-17
Genzyme Corporation FABRAZYME agalsidase beta For Injection 103979 2003-10-10 ⤷  Try it Free 2029-11-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson

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