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Last Updated: September 24, 2020

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Patent: 10,059,762

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Summary for Patent: 10,059,762
Title:Anti-EGFR activatable antibodies
Abstract: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolyzed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolyzing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
Inventor(s): Stagliano; Nancy Elizabeth (San Francisco, CA), West; James William (Bend, OR), Kamath; Kathryn (Santa Barbara, CA), Bessette; Paul Henry (San Francisco, CA), Gluck; Fred (Santa Barbara, CA), Sagert; Jason Gary (San Mateo, CA), Daugherty; Patrick (Santa Barbara, CA)
Assignee: CytomX Therapeutics, Inc. (South San Francisco, CA)
Application Number:15/140,944
Patent Claims:see list of patent claims

Details for Patent 10,059,762

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial CytomX Therapeutics, Inc. (South San Francisco, CA) 2029-01-12 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial CytomX Therapeutics, Inc. (South San Francisco, CA) 2029-01-12 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial CytomX Therapeutics, Inc. (South San Francisco, CA) 2029-01-12 DISCN search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial CytomX Therapeutics, Inc. (South San Francisco, CA) 2029-01-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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