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Last Updated: September 24, 2022

Patent: 10,046,058


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Summary for Patent: 10,046,058
Title:Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
Abstract: Examples may include a microsphere. The microsphere may include a biodegradable polymer. Furthermore, the microsphere may include a protein mixture selected from the group consisting of a protein-polyethylene glycol conjugate, the protein-polyethylene glycol conjugate and the hydrophobic anion of the organic acid, a protein and the hydrophobic anion of the organic acid, and combinations thereof. Examples may also include a method of making the microspheres. The method may further include reacting a polyethylene glycol with a protein to form a protein-PEG conjugate. In addition, the method may include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid to form the protein-PEG conjugate salt. Furthermore, the method may include mixing the protein-PEG conjugate salt in an organic solvent with a biodegradable polymer. The method may also include emulsifying the mixture. Additionally, the method may include hardening the emulsified mixture into the controlled-release microspheres.
Inventor(s): Rosendahl; Mary S. (Broomfield, CO), Mantripragada; Sankaram B. (Windsor, CO), Gomez; Eliana B. (Boulder, CO)
Assignee: REZOLUTE, INC. (Louisville, CO)
Application Number:14/954,591
Patent Claims:see list of patent claims

Details for Patent 10,046,058

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 See Plans and Pricing 2034-12-02
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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