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Last Updated: July 28, 2021

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Patent: 10,046,058

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Summary for Patent: 10,046,058
Title:Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
Abstract: Examples may include a microsphere. The microsphere may include a biodegradable polymer. Furthermore, the microsphere may include a protein mixture selected from the group consisting of a protein-polyethylene glycol conjugate, the protein-polyethylene glycol conjugate and the hydrophobic anion of the organic acid, a protein and the hydrophobic anion of the organic acid, and combinations thereof. Examples may also include a method of making the microspheres. The method may further include reacting a polyethylene glycol with a protein to form a protein-PEG conjugate. In addition, the method may include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid to form the protein-PEG conjugate salt. Furthermore, the method may include mixing the protein-PEG conjugate salt in an organic solvent with a biodegradable polymer. The method may also include emulsifying the mixture. Additionally, the method may include hardening the emulsified mixture into the controlled-release microspheres.
Inventor(s): Rosendahl; Mary S. (Broomfield, CO), Mantripragada; Sankaram B. (Windsor, CO), Gomez; Eliana B. (Boulder, CO)
Assignee: REZOLUTE, INC. (Louisville, CO)
Application Number:14/954,591
Patent Claims:see list of patent claims

Details for Patent 10,046,058

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ⤷  Free Forever Trial REZOLUTE, INC. (Louisville, CO) 2034-12-02 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ⤷  Free Forever Trial REZOLUTE, INC. (Louisville, CO) 2034-12-02 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ⤷  Free Forever Trial REZOLUTE, INC. (Louisville, CO) 2034-12-02 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ⤷  Free Forever Trial REZOLUTE, INC. (Louisville, CO) 2034-12-02 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,046,058

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2016089818 ⤷  Free Forever Trial
United States of America 10702611 ⤷  Free Forever Trial
United States of America 2016151510 ⤷  Free Forever Trial
United States of America 2016151511 ⤷  Free Forever Trial
United States of America 2018318429 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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