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Last Updated: October 6, 2022

Patent: 10,016,412


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Summary for Patent: 10,016,412
Title:TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
Inventor(s): Spiegel; David (New Haven, CT), Fitzgerald; Kelly (New Haven, CT)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:15/374,272
Patent Claims:see list of patent claims

Details for Patent 10,016,412

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Teknika Llc TICE BCG bcg live For Injection 102821 06/21/1989 See Plans and Pricing 2021-05-01
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 See Plans and Pricing 2021-05-01
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 See Plans and Pricing 2021-05-01
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 See Plans and Pricing 2021-05-01
Hoffmann-la Roche Inc. ROFERON-A interferon alfa-2a For Injection 103145 06/04/1986 See Plans and Pricing 2021-05-01
Clinigen, Inc. PROLEUKIN aldesleukin For Injection 103293 05/05/1992 See Plans and Pricing 2021-05-01
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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