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Last Updated: September 26, 2022

Patent: 10,011,659


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Summary for Patent: 10,011,659
Title:Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (TKI)
Abstract: Methods of treating a subject having cancer exhibiting a resistance to a tyrosine kinase inhibitor (TKI) are provided. Accordingly, there is provided a method comprising administering to the subject a therapeutically effective amount of antibodies comprising an anti-EGFR antibody, an anti-HER2 antibody and an anti-HER3 antibody. Also provided are compositions and articles of manufacture for treating cancer resistance to a TKI. Also provided are methods of treating non-resistant tumors.
Inventor(s): Yarden; Yosef (Rehovot, IL), Mancini; Maicol (Rehovot, IL), Gaborit; Nadege (Rehovot, IL)
Assignee: Yeda Research and Development Co. Ltd. (Rehovot, IL)
Application Number:14/956,585
Patent Claims:see list of patent claims

Details for Patent 10,011,659

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 See Plans and Pricing 2034-09-08
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 See Plans and Pricing 2034-09-08
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 See Plans and Pricing 2034-09-08
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 See Plans and Pricing 2034-09-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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