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Last Updated: September 25, 2020

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Patent: 10,011,659

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Summary for Patent: 10,011,659
Title:Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (TKI)
Abstract: Methods of treating a subject having cancer exhibiting a resistance to a tyrosine kinase inhibitor (TKI) are provided. Accordingly, there is provided a method comprising administering to the subject a therapeutically effective amount of antibodies comprising an anti-EGFR antibody, an anti-HER2 antibody and an anti-HER3 antibody. Also provided are compositions and articles of manufacture for treating cancer resistance to a TKI. Also provided are methods of treating non-resistant tumors.
Inventor(s): Yarden; Yosef (Rehovot, IL), Mancini; Maicol (Rehovot, IL), Gaborit; Nadege (Rehovot, IL)
Assignee: Yeda Research and Development Co. Ltd. (Rehovot, IL)
Application Number:14/956,585
Patent Claims:see list of patent claims

Details for Patent 10,011,659

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Yeda Research and Development Co. Ltd. (Rehovot, IL) 2034-09-08 RX Orphan search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Yeda Research and Development Co. Ltd. (Rehovot, IL) 2034-09-08 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Yeda Research and Development Co. Ltd. (Rehovot, IL) 2034-09-08 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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