Patent: 10,004,770
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Summary for Patent: 10,004,770
Title: | Production and use of bacterial histamine |
Abstract: | A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions. |
Inventor(s): | Versalovic; James (Houston, TX), Thomas; Carissa Michelle (Houston, TX), Connolly; Eamonn (Lindingo, SE) |
Assignee: | BIOGAIA AB (Stockholm, SE) |
Application Number: | 15/289,666 |
Patent Claims: | see list of patent claims |
Details for Patent 10,004,770
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Jubilant Hollisterstier Llc | N/A | positive skin test control-histamine | Injection | 103891 | 03/13/1924 | ⤷ Try a Trial | 2031-07-21 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |