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Last Updated: March 28, 2024

Patent: 10,004,770


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Summary for Patent: 10,004,770
Title:Production and use of bacterial histamine
Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.
Inventor(s): Versalovic; James (Houston, TX), Thomas; Carissa Michelle (Houston, TX), Connolly; Eamonn (Lindingo, SE)
Assignee: BIOGAIA AB (Stockholm, SE)
Application Number:15/289,666
Patent Claims:see list of patent claims

Details for Patent 10,004,770

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Jubilant Hollisterstier Llc N/A positive skin test control-histamine Injection 103891 03/13/1924 ⤷  Try a Trial 2031-07-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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