Last Updated: May 10, 2026

Patent: 10,421,984

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Summary for Patent: 10,421,984

Title:	Methods for reducing norleucine misincorporation into proteins using a microorganism comprising a mutant metA allele
Abstract:	The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
Inventor(s):	Laird Michael W., Veeravalli Karthik
Assignee:	Genentech, Inc.
Application Number:	US15951895
Patent Claims:	see list of patent claims

Details for Patent 10,421,984

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	10,421,984	2038-04-12
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	August 10, 2012	10,421,984	2038-04-12
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	October 13, 2016	10,421,984	2038-04-12
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	March 20, 2018	10,421,984	2038-04-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,421,984

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Country	Patent Number	Estimated Expiration
South Africa	201501653	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2014047311	⤷ Start Trial
United States of America	9850514	⤷ Start Trial
United States of America	2020056218	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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