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Last Updated: January 29, 2022

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Claims for Patent: 9,931,402

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Summary for Patent: 9,931,402
Title:Compositions for the treatment of solid tumors
Abstract: The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of medicament for the treatment of cancer; a kit comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and a method of treating cancer in a subject, especially a human.
Inventor(s): Hurwitz; Herbert I. (Durham, NC), Vlahovic; Gordana (Durham, NC)
Assignee: Duke University (Durham, NC)
Application Number:15/586,727
Patent Claims:1. A pharmaceutical composition comprising an IGF1R inhibitor and an mTOR inhibitor in a pharmaceutically acceptable carrier, wherein the IGF1R inhibitor is ganitumab and the mTOR inhibitor is everolimus.

2. The composition of claim 1, wherein the composition comprises ganitumab is in an amount of about 0.05 mg to about 5 g.

3. The composition of claim 1, wherein the composition comprises ganitumab is in an amount of about 0.5 mg to about 5 g.

4. The composition of claim 1, wherein the composition comprises ganitumab is in an amount of about 1 mg to about 2 g.

5. The composition of claim 1, wherein the composition comprises everolimus in an amount of about 0.1 mg to about 10 mg.

6. The composition of claim 1, wherein the composition comprises everolimus in an amount of about 2 mg to about 8 mg.

7. The composition of claim 1, wherein the composition comprises everolimus in an amount of about 5 mg.

8. A kit comprising an IGF1R inhibitor and an mTOR inhibitor, wherein the IGF1R inhibitor is ganitumab and the mTOR inhibitor is everolimus, and printed instructions directing the use of a combined treatment of ganitumab and everolimus for treating cancer in a subject.

9. The kit of claim 8, wherein the ganitumab and the everolimus are in separate containers.

10. The kit of claim 9, wherein the ganitumab and the everolimus are in separate containers.

11. The kit of claim 8, wherein the ganitumab and the everolimus are in a unit dosage form.

12. The kit of claim 11, herein the ganitumab and the everolimus are in the same containers.

13. The kit of claim 8, further comprising a sterile diluent.

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