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Last Updated: December 16, 2025

Claims for Patent: 9,885,024

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Summary for Patent: 9,885,024

Title:	PEG-urate oxidase conjugates and use thereof
Abstract:	A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Inventor(s):	L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
Assignee:	Duke University , Horizon Therapeutics USA Inc
Application Number:	US14/806,494

Details for Patent 9,885,024

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Horizon Therapeutics Ireland Dac	KRYSTEXXA	pegloticase	Injection	125293	September 14, 2010	9,885,024	2035-07-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,885,024

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Country	Patent Number	Estimated Expiration
South Africa	200207206	⤷ Get Started Free
South Africa	200101814	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	0159078	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	0007629	⤷ Get Started Free
United States of America	8921064	⤷ Get Started Free
United States of America	8618267	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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