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Last Updated: December 16, 2025

Claims for Patent: 9,879,063

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Summary for Patent: 9,879,063

Title:	Engineered polypeptides having enhanced duration of action and reduced immunogenicity
Abstract:	Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.
Inventor(s):	Mary Erickson, David C. LITZINGER, Soumitra S. Ghosh, Zijian Guo, Caroline Ekblad, Jonathan D. Roth
Assignee:	Novelion Therapeutics Inc , Amryt Pharmaceuticals Inc
Application Number:	US14/837,705

Details for Patent 9,879,063

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Chiesi Farmaceutici S.p.a.	MYALEPT	metreleptin	For Injection	125390	February 24, 2014	⤷ Get Started Free	2035-08-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,879,063

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2013009539	⤷ Get Started Free
United States of America	2018305430	⤷ Get Started Free
United States of America	2016207974	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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