Claims for Patent: 9,850,239

Summary for Patent: 9,850,239

Title:	Pyrazolo[3,4-c]pyridine compounds and methods of use
Abstract:	Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R.sup.1 and R.sup.2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. ##STR00001##
Inventor(s):	Do; Steven (San Jose, CA), Hu; Huiyong (San Mateo, CA), Kolesnikov; Aleksandr (San Francisco, CA), Lee; Wendy (San Ramon, CA), Tsui; Vickie Hsiao-Wei (Burlingame, CA), Wang; Xiaojing (Foster City, CA), Wen; Zhaoyang (San Francisco, CA)
Assignee:	Genentech, Inc. (South San Francisco, CA)
Application Number:	15/044,231
Patent Claims:	1. A method of treating a disease or disorder which method comprises administering a therapeutically effective amount of a compound of Formula I: ##STR00521## and stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: R.sup.1 is selected from C.sub.2-C.sub.20 heterocyclyl, C.sub.1-C.sub.20 heteroaryl, --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-O--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-O--(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-NR.sup.3--(C.sub.2-C.sub.20 heterocyclyl), and --(C.sub.1-C.sub.20 heteroaryl)-NR.sup.3--(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl); R.sub.2 is selected from C.sub.2-C.sub.20 heterocyclyl, C.sub.1-C.sub.20 heteroaryl, C.sub.6-C.sub.20 aryl, --(C.sub.6-C.sub.20 aryl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-NR.sup.3--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.20 heteroaryl)-NR.sup.3--(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), and --(C.sub.1-C.sub.20 heteroaryl)-NR.sub.3--(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl); R.sub.3 is independently selected from H and C.sub.1-C.sub.12 alkyl optionally substituted with F, Cl, CN, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, and --S(O).sub.2CH.sub.3; where alkyl, alkylene, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2NH.sub.2, --CH.sub.2NHCH.sub.3, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, CH.sub.2CH(CH.sub.3)NH.sub.2, --CH.sub.2CONH.sub.2, --CH.sub.2OH, --CH.sub.2CH.sub.2OH, --C(CH.sub.3).sub.2OH, --CH(OH)CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CH.sub.2OH, --CH.sub.2C(CH.sub.3).sub.2OH, --CH.sub.2CH.sub.2SO.sub.2CH.sub.3, --CN, --CF.sub.3, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CONH.sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, --CH.sub.2OCH.sub.3, --S(O).sub.2CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino; to a patient with a disease or disorder selected from cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders, and mediated by Pim kinase. 2. The method of claim 1 wherein the disease or disorder is cancer selected from multiple myeloma, breast, ovary, cervix, prostate, testis, genitourinary tract, esophagus, larynx, glioblastoma, neuroblastoma, stomach, skin, keratoacanthoma, lung, epidermoid carcinoma, large cell carcinoma, non-small cell lung carcinoma (NSCLC), small cell carcinoma, lung adenocarcinoma, bone, colon, adenoma, pancreas, adenocarcinoma, thyroid, follicular carcinoma, undifferentiated carcinoma, papillary carcinoma, seminoma, melanoma, sarcoma, bladder carcinoma, liver carcinoma and biliary passages, kidney carcinoma, pancreatic, myeloid disorders, lymphoma, hairy cells, buccal cavity, naso-pharyngeal, pharynx, lip, tongue, mouth, small intestine, colon-rectum, large intestine, rectum, brain and central nervous system, Hodgkin's, leukemia, bronchus, thyroid, liver and intrahepatic bile duct, hepatocellular, gastric, glioma/glioblastoma, endometrial, melanoma, kidney and renal pelvis, urinary bladder, uterine corpus, uterine cervix, acute myelogenous leukemia, chronic myelogenous leukemia, lymphocytic leukemia, myeloid leukemia, oral cavity and pharynx, non-Hodgkin lymphoma, melanoma, and villous colon adenoma. 3. The method of claim 2 further comprising administering an additional therapeutic agent selected from a chemotherapeutic agent, an anti-inflammatory agent, an immunomodulatory agent, a neurotropic factor, an agent for treating cardiovascular disease, an agent for treating liver disease, an anti-viral agent, an agent for treating blood disorders, an agent for treating diabetes, and an agent for treating immunodeficiency disorders. 4. The method of claim 3 wherein the additional therapeutic agent is selected from dexamethasone, thioTEPA, doxorubicin, vincristinc, rituximab, cyclophosphamide, prednisone, melphalan, lenalidomide, bortezomib, rapamycin, and cytarabine. 5. The method of claim 1 wherein R.sup.1 is C.sub.1-C.sub.20 heteroaryl. 6. The method of claim 1 wherein R.sup.1 is selected from the structures: ##STR00522## where the wavy line indicates the site of attachment. 7. The method of claim 1 wherein R.sup.2 is C.sub.1-C.sub.20 heteroaryl. 8. The method of claim 1 wherein R.sup.2 is --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.2-C.sub.20 heterocyclyl). 9. The method of claim 1 wherein R.sub.2 is selected from the structures: ##STR00523## where the wavy line indicates the site of attachment; and R.sup.4 is selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2NH.sub.2, --CH.sub.2NHCH.sub.3, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH(CH.sub.3)NH.sub.2, --CH.sub.2CONH.sub.2, --CH.sub.2OH, --CH.sub.2CH.sub.2OH, --C(CH.sub.3).sub.2OH, --CH(OH)CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CH.sub.2OH, --CH.sub.2C(CH.sub.3).sub.2OH, --CH.sub.2CH.sub.2SO.sub.2CH.sub.3, --CN, --CF.sub.3, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CONH.sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, --CH.sub.2OCH.sub.3, --S(O).sub.2CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino; and n is 0, 1, or 2. 10. The method of claim 1 having the structure of Formula Ia: ##STR00524## where R.sup.4 is selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2NH.sub.2, --CH.sub.2NHCH.sub.3, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH(CH.sub.3)NH.sub.2, --CH.sub.2CONH.sub.2, --CH.sub.2OH, --CH.sub.2CH.sub.2OH, --C(CH.sub.3).sub.2OH, --CH(OH)CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CH.sub.2OH, --CH.sub.2C(CH.sub.3).sub.2OH, --CH.sub.2CH.sub.2SO.sub.2CH.sub.3, --CN, --CF.sub.3, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CONH.sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, --CH.sub.2OCH.sub.3, --S(O).sub.2CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-ypethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino; and n is 0, 1, or 2. 11. The method of claim 1 having the structure of Formula 1b: ##STR00525## where R.sup.3 is selected from H, C.sub.3-C.sub.12 carbocyclyl, and C.sub.1-C.sub.12 alkyl where carbocyclyl and alkyl are optionally substituted with F, Cl, CN, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, and --S(O).sub.2CH.sub.3. 12. The method of claim 1 having the structure of Formula 1c: ##STR00526## where R.sup.4 is selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2NH.sub.2, --CH.sub.2NHCH.sub.3, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CHCH.sub.2NH.sub.2, --CH.sub.2CHCH.sub.2CH.sub.2NH.sub.2, --CH.sub.2CH(CH.sub.3)NH.sub.2, --CH.sub.2CONH.sub.2, --CH.sub.2OH, --CH.sub.2CH.sub.2OH, --C(CH.sub.3).sub.2OH, --CH(OH)CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CH.sub.2OH, --CH.sub.2C(CH.sub.3).sub.2OH, --CH.sub.2CH.sub.2SO.sub.2CH.sub.3, --CN, --CF.sub.3, --CO.sub.2H, --COCH.sub.3, --CO.sub.2CH.sub.3, --CO.sub.2C(CH.sub.3).sub.3, --COCH(OH)CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CONH.sub.2, --NO.sub.2, --NH.sub.2, --NHCH.sub.3, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --N(CH.sub.3)COCH.sub.3, --NHS(O).sub.2CH.sub.3, --NHCH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2NH.sub.2, --NHCH.sub.2CH.sub.2CH.sub.2CH.sub.2NH.sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, .dbd.O, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.2OCH.sub.3, --OCH.sub.2CH.sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --SCH.sub.3, --CH.sub.2OCH.sub.3, --S(O).sub.2CH.sub.3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino; and n is 0, 1, or 2. 13. The method of claim 1, wherein said compound is selected from the group consisting of: 3-phenyl-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-yl)- piperidin-3-amine; 3-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)benzamide; 5-(pyridin-3-yl)-3-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-c]pyridine- ; 1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-yl)pip- eridin-4-amine; 3-(2-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- e; (S)-(1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-- yl)pyrrolidin-3-yl)methanamine; 3-(6-fluoropyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; 6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2(1H)-one; 5-(1-methyl-1H-pyrazol-4-yl)-3-phenyl-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; 3-phenyl-5-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-c]pyridine; 1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-yl)azep- an-4-amine; (S)-(1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-yl- )piperidin-3-yl)methanamine; (R)-1-(3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-4-yl)- piperidin-3-amine; 3-phenyl-5-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[3,4-c]pyridine; N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)ethan- e-1,2-diamine; 1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperi- din-4-amine; 5-(1H-imidazol-1-yl)-3-phenyl-1H-pyrazolo[3,4-c]pyridine; 1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)pipe- ridin-4-amine; (S)-3-(2-fluorophenyl)-5-(4-(piperidin-3-yloxy)pyridin-3-yl)-1H-pyrazolo[- 3,4-c]pyridine; (R)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-amine; 3-phenyl-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- pyrrolidin-3-amine; (S)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- piperidin-3-amine; (R)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- piperidin-3-amine; (R)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- pyrrolidin-3-amine; 3-(2-fluorophenyl)-5-(4-(piperidin-4-ylmethoxy)pyridin-3-yl)-1H-pyrazolo[- 3,4-c]pyridine; 3-(1H-pyrazol-4-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; 1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)pipe- ridin-4-amine; 1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-3-yl)piperi- din-4-amine; N1-(4-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)ethan- e-1,2-diamine; 1-(4-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperi- din-4-amine; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-amine; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyr- idine; 3,5-bis(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; (R)-(1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl- )pyrrolidin-3-yl)methanamine; (1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-3-yl)piper- idin-4-yl)methanamine; 1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)azep- an-4-amine; (1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)pip- eridin-4-yl)methanamine; (R)-(1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-3-yl)p- yrrolidin-3-yl)methanamine; 1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-3-yl)azepan- -4-amine; N-(piperidin-4-yl)-5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-3-amine; 5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-N-(piperidin-4-yl)p- yridin-3-amine; 3-(2-fluoro-5-methoxyphenyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4- -c]pyridine; (S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)piperidin-3-amine; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-4-amine; 3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c- ]pyridine; 3,5-di(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; (R)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)piperidin-3-amine; 2-(4-(3-(6-fluoropyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-1H-pyrazol- -1-yl)acetamide; (S)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- azepan-4-amine; (S)-1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)- piperidin-3-amine; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(tetrahydro-2H-pyran-3-yl)-H-pyrazol- o[3,4-c]pyridine; (1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-4-yl)methanamine; 6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-N-(piperi- din-4-ylmethyl)pyridin-2-amine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)- -1H-pyrazolo[3,4-c]pyridine; 5-(furan-3-yl)-3-phenyl-1H-pyrazolo[3,4-c]pyridine; 3-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)-5-(pyridin-3-yl)-1H-pyrazolo- [3,4-c]pyridine; 3-(6-(1,4-diazepan-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]- pyridine; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl)azepan-4-amine; (R)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)pyrrolidin-3-amine; (S)-1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)- pyrrolidin-3-amine; (R)-1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-amine; (R)-1-(5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl)- pyrrolidin-3-amine; 3-(1H-pyrazol-3-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; 5-(pyridin-3-yl)-3-(pyridin-4-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(4-(piperidin-4-yloxy)pyridin-3-yl)-H-pyrazolo[3,4-c- ]pyridine; (S)-1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyrid- in-2-yl)piperidin-3-amine; 1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)azepan- -4-amine; 5-(4-(azetidin-3-yloxy)pyridin-3-yl)-3-(2-fluorophenyl)-1H-pyraz- olo[3,4-c]pyridine; (R)-3-(2-fluorophenyl)-5-(4-(piperidin-3-ylmethoxy)pyridin-3-yl)-H-pyrazo- lo[3,4-c]pyridine; 6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-N-(piperi- din-4-yl)pyridin-2-amine; (S)-3-(2-fluorophenyl)-5-(4-(piperidin-3-ylmethoxy)pyridin-3-yl)-1H-pyraz- olo[3,4-c]pyridine; (S)-1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)py- rrolidin-3-amine; (R)-1-(5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)py- rrolidin-3-amine; 3-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluoro-5-methylphenyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-- c]pyridine; (S)-1-(6-(5-(5-fluoropyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-amine; 3-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-N-(piperidin-4-ylme- thyl)pyridin-4-amine; 5-(5-fluoropyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3- ,4-c]pyridine; (R)-3-(2-fluorophenyl)-5-(4-(pyrrolidin-3-ylmethoxy)pyridin-3-yl)-1H-pyra- zolo[3,4-c]pyridine; (R)-1-(6-(5-(5-fluoropyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-amine; (S)-3-(2-fluorophenyl)-5-(4-(pyrrolidin-3-ylmethoxy)pyridin-3-yl)-1H-pyra- zolo[3,4-c]pyridine; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(tetrahydrofuran-3-yl)-1H-pyrazolo[3- ,4-c]pyridine; 5-(1H-imidazol-5-yl)-3-phenyl-1H-pyrazolo[3,4-c]pyridine; 3-phenyl-5-(pyrazin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(1-(piperidin-4-yl)-1H-pyrazol-3-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c- ]pyridine; 3-(6-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-2-yl)-- 5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; N-(2-(1H-imidazol-4-yl)ethyl)-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo- [3,4-c]pyridin-3-yl)pyridin-2-amine; 3-(2-fluorophenyl)-5-(1H-imidazol-5-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(pyrazin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(2-fluorophenyl)-5-(4-(2-(piperidin-4-yl)ethoxy)pyridin-3-yl)-H-pyrazol- o[3,4-c]pyridine; 1-(6-(3-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin- -2-yl)piperidin-4-amine; (R)-1-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)phe- nyl)piperidin-3-amine; 1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-- 5-yl)piperazin-2-one; 1-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)urea- ; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)azepan-3-amine; (S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)azepan-4-amine; 4-amino-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-y- l)piperidine-4-carboxamide; 1-(6-(3-(2,6-difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- piperidin-4-amine; 1-(6-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)piperidin-4-am- ine; 3-(1-methyl-1H-pyrazol-3-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyrid- ine; 1-(6-(3-(1-methyl-1H-pyrazol-3-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyr- azin-2-yl)piperidin-4-amine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazo- lo[3,4-c]pyridine; 4-amino-N-methyl-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)py- ridin-2-yl)piperidine-4-carboxamide; (R)-2-(1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl- )piperidin-3-yl)ethanamine; 3-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyri- din-2-amine; 3-(piperazin-1-yl)-5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)ben- zonitrile; 1-(3-chloro-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)- pyridin-2-yl)piperidin-4-amine; (S)-2-(1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl- )piperidin-3-yl)ethanamine; 1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-- yl)piperidin-4-amine; (R)-1-(6-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrazin-2-yl)- azepan-4-amine; (R)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)azepan-4-amine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(6-(piperidin-4-yl)pyridin-2-yl)-1H-pyrazo- lo[3,4-c]pyridine; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)az- epan-4-amine; (R)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)az- epan-4-amine; 2-methyl-1-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)-1H-pyrazol-1-yl)propan-2-ol; 5-(pyridin-3-yl)-3-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-c]pyridine; 1-methyl-3-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)imidazolidin-- 2-one; 3-(5-chloro-6-(4-methylpiperazin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl- )-1H-pyrazolo[3,4-c]pyridine; 3,5-di(pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(5-methyl-6-(4-methylpiperazin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-p- yrazolo[3,4-c]pyridine; 1-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyrrolidin-2-one; 1-methyl-4-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)-1H-pyrrol-2(5H)-one; 1-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)piperidin-2-one; 3-(6-(piperidin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyr- idine; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)p- yridin-2-yl)piperidin-3-ol; 1-methyl-4-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)pyrrolidin-2-one; (R)-5-(1-methyl-1H-pyrazol-4-yl)-3-(6-(piperidin-3-yloxy)pyridin-2-yl)-1H- -pyrazolo[3,4-c]pyridine; (S)-1-(3-chloro-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; (R)-1-(3-chloro-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; 4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)morpho- line; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-- yl)pyrrolidin-3-amine; (S)-(1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)p- yrrolidin-3-yl)methanamine; (R)-(1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)p- yrrolidin-3-yl)methanamine; (R)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-ol; 1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperi- din-4-ol; 3-(6-(4,4'-bipiperidin-1-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-py- razolo[3,4-c]pyridine; 3-(6-fluoro-5-methylpyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyri- dine; 3-(5-methylpyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine- ; (R)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)p- yrrolidin-3-amine; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-ol; (1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piper- idin-4-yl)methanamine; 4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pipera- zin-2-one; N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)propane-1,3-diamine; 3-(3,4-dihydro-2H-pyran-5-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine- ; 2-(4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- perazin-1-yl)ethanol; N1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)butan- e-1,4-diamine; 3-(4,5-dihydrofuran-3-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridine; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)piperidin-3-amine; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)-3-(trifluoromethyl)pyrrolidin-3-amine; (R)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)pyrrolidin-3-amine; 1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-- yl)piperidin-4-ol; (S)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-amine; (R)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-amine; (R)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-ol; 1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-y- l)piperidin-4-ol; (R)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)pyrrolidin-3-ol; 1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-4-ol; 2-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-2,8-diazaspiro[4.5]de- can-1-one; 1-(piperidin-4-ylmethyl)-3-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]- pyridin-3-yl)imidazolidin-2-one; 2-methyl-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-ylamino)propan-2-ol; (R)-1-(4-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyrimidin-2-yl)- piperidin-3-amine; 1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pipera- zin-2-one; 2-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)isonicotinam- ide; 1-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-(pyrrolidin-3-y- lmethyl)imidazolidin-2-one; (S)-3-amino-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)pyrrolidin-2-one; (S)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)pyrrolidin-3-ol; (R)-1-(3-methyl-6-(5-pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-1)pyridin-- 2-yl)pyrrolidin-3-ol; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-vinylpyridin- -2-yl)piperidin-3-amine; (S)-1-(3-(prop-1-en-2-yl)-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3- -yl)pyridin-2-yl)piperidin-3-amine; (R)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-ol; (R)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; (R)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl) azepan-4-amine; (S)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)azepan-4-amine; (R)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)azepan-4-amine; (S)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)azepan-4-amine; (S)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; (R)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)pyrrolidin-3-amine; (S)-1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)pyrrolidin-3-amine; (S)-1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)pyrrolidin-3-ol; (1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piper- idin-3-yl)methanamine; 3-(3-(piperazin-1-yl)pyrrolidin-1-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]- pyridine; (3S,5R)-5-fluoro-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridi- n-3-yl)pyridin-2-yl)piperidin-3-amine; 4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)-1,4-d- iazepan-2-one; 5-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)thiazole; (1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piper- idin-2-yl)methanamine; 3-(4-aminopiperidine-1-carbonyl)-1-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]py- ridin-3-yl)pyrrolidin-2-one; N-(2-aminoethyl)-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)picol- inamide; (S)-1-(3-ethyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl- )pyridin-2-yl)piperidin-3-amine; (S)-1-(3-isopropyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)piperidin-3-amine; N-(azetidin-3-yl)-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pico- linamide; 1-methyl-4-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)piperazin-2-- one; 1-methyl-4-(3-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-5-- yl)piperazin-2-one; 5-(1-methyl-1H-pyrazol-4-yl)-3-(pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 2-(1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pyr- rolidin-3-yl)ethanamine; (S)-3-amino-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -3-yl)pyrrolidin-2-one; 4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pipe- razin-2-one; (4-aminopiperidin-1-yl)(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl)methanone; N-(piperidin-4-yl)-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pic- olinamide; 5-(3-(pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)thiazole; 4-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-1-methylpiperazin-2- -one; (S)-1-(3-ethynyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)- pyridin-2-yl)piperidin-3-amine; (S)-3-methyl-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-3-yl)py- rrolidine-2-carboxamide; (S)-4-(3-(6-(3-aminopiperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridi- n-5-yl)piperazin-2-one; 1-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)pipe- razin-2-one; (R)-3-methyl-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; 5-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)thiazole; (S)-1-(6-(5-(thiazol-5-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-amine; (R)-1-(6-(5-(thiazol-5-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)pi- peridin-3-amine; 1-methyl-4-(3-(pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)piperazin-2-o- ne; 2-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-5-(trifluoromethyl- )pyridine 1-oxide; 3-methyl-1-(3-phenyl-1H-pyrazolo[3,4-c]pyridin-5-yl)imidazolidine-2,4-dio- ne; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyra- zolo[3,4-c]pyridine; 2-(4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)-1,- 4-diazepan-1-yl)ethanol; 5-(3-(6-(piperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)thia- zole; 5-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl- )thiazole; 5-(1-methyl-1H-pyrazol-4-yl)-3-(2-(piperidin-1-yl)pyrimidin-4-y- l)-1H-pyrazolo[3,4-c]pyridine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(2-(piperazin-1-yl)pyrimidin-4-yl)-1H-pyra- zolo[3,4-c]pyridine; (S)-1-(3-butyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperidin-3-amine; 5-(1H-imidazol-1-yl)-3-(6-(piperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c- ]pyridine; (R)-1-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridi- n-3-yl)pyrimidin-2-yl)piperidin-3-amine; (S)-1-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- imidin-2-yl)piperidin-3-amine; 1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-- 5-yl)pyridin-2(1H)-one; 5-(6-methylpyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3- ,4-c]pyridine; 5-(1H-imidazol-1-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c- ]pyridine; (R)-1-(6-(5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)p- yridin-2-yl)piperidin-3-amine; (R)-3-(3-(6-(3-aminopiperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridi- n-5-yl)oxazolidin-2-one; 3-methyl-1-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-- 5-yl)imidazolidine-2,4-dione; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(4-methylpiperazin-1-yl)pyridin-2-yl)-1H- -pyrazolo[3,4-c]pyridine; 3-(3-(6-(piperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)oxaz- olidin-2-one; (S)-3-(3-(6-(3-aminopiperidin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridi- n-5-yl)oxazolidin-2-one; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(1-propyl-1H-pyrazol-4-yl)-1H-pyrazo- lo[3,4-c]pyridine; (S)-1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)piperidin-3-amine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-N-methylpiperidin-3-amine; 5-(6-fluoropyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3- ,4-c]pyridine; 1-(3-amino-2,2-dimethylpropyl)-5-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyri- din-3-yl)pyridin-2(1H)-one; (S)-1-(6-(5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-y- l)piperidin-3-amine; 5-(1-isobutyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyra- zolo[3,4-c]pyridine; 5-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)- -1H-pyrazolo[3,4-c]pyridine; 3-methyl-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl)piperidin-3-ol; 5-(5-methylpyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3- ,4-c]pyridine; (3S,5R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)- pyridin-2-yl)-5-fluoropiperidin-3-amine; (S)-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-(trifluorome- thyl)pyridin-2-yl)piperidin-3-amine; 4-(1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3- -yl)pyridin-2-yl)azetidin-3-yl)-1,1-dioxothiomorpholine; 2-methyl-1-(4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyrid- in-5-yl)-1H-pyrazol-1-yl)propan-2-ol; 5-(1-isopropyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyr- azolo[3,4-c]pyridine; 5-(1-cyclobutyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-py- razolo[3,4-c]pyridine; 5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-- 1H-pyrazolo[3,4-c]pyridine; 1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl- )pyridin-2-yl)piperidin-4-amine; (S)-1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)piperidin-3-ol; (R)-1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)piperidin-3-ol; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol- -2(1H)-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(3-methylpiperazin-1-yl)pyridin-2-yl- )-1H-pyrazolo[3,4-c]pyridine; (R)-5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(3-methylpiperazin-1-yl)pyridin-2-yl- )-1H-pyrazolo[3,4-c]pyridine; 4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)morp- holine; 3-(5-bromo-6-(4-methylpiperazin-1-yl)pyridin-2-yl)-5-(1-methyl-1H-- pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(3-bromo-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3- -yl)pyridin-2-yl)piperidin-3-amine; 3-(5-bromo-6-(piperazin-1-yl)pyridin-2-yl)-5-(1-ethyl-1H-pyrazol-4-yl)-1H- -pyrazolo[3,4-c]pyridine; 4-(1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3- -yl)pyridin-2-yl)azetidin-3-yl)piperazin-2-one; 3-(5-bromo-6-(3,3-dimethyl-4-(2-(methylsulfonyl)ethyl)piperazin-1-yl)pyri- din-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; (R)-1-(3-bromo-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3- -yl)pyridin-2-yl)piperidin-3-amine; 4-(1-(3-bromo-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)azetidin-3-yl)piperazin-2-one; 3-(6-(1,4-diazepan-1-yl)pyridin-2-yl)-5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyra- zolo[3,4-c]pyridine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-1,4-diazepan-6-ol; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-1,4-diazepan-6-ol; (S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-- vinylpyridin-2-yl)piperidin-3-amine; 4-(1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)azetidin-3-yl)-1,1-dioxo thiomorpholine; (S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-- (prop-1-en-2-yl)pyridin-2-yl)piperidin-3-amine; 3-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)oxaz- olidin-2-one; 5-(1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-- yl)-1H-pyrazolo[3,4-c]pyridine; 1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl)piperidin-4-amine; (R)-1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)piperidin-3-ol; 4-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl) morpholine; 4-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl) morpholine; 3-(6-(4-fluoropiperidin-4-yl)pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3- ,4-c]pyridine; 4-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperi- din-4-ol; (S)-3-methyl-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-- c]pyridin-3-yl)pyridin-2-yl)piperidin-3-ol; (R)-3-methyl-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)piperidin-3-ol; 4-(1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)azetidin-3-yl)piperazin-2-one; 4-(1-(3-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)azetidin-3-yl)piperazin-2-one; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-(- prop-1-en-2-yl)pyridin-2-yl)piperidin-3-amine; 3-(6-(3,3-dimethyl-4-(2-(methylsulfonyl)ethyl)piperazin-1-yl)-5-methylpyr- idin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(3-ethyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)piperidin-3-amine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-m- ethylpyridin-2-yl)piperidin-3-amine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-v- inylpyridin-2-yl)piperidin-3-amine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(5-methyl-6-(piperazin-1-yl)pyridin-2-yl)-1- H-pyrazolo[3,4-c]pyridine; (S)-1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)piperidin-3-amine; (S)-1-(3-isopropyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyri- din-3-yl)pyridin-2-yl)piperidin-3-amine; 4-fluoro-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-- yl)piperidin-3-ol; 5-(5-methoxypyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[- 3,4-c]pyridine; N-methyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-ami- ne; 5-(5-ethylpyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo- [3,4-c]pyridine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(2-(piperidin-4-yl)pyrimidin-4-yl)-1H-pyra- zolo[3,4-c]pyridine; 5-(1-methyl-1H-pyrazol-4-yl)-3-(5-methyl-6-(4-methylpiperazin-1-yl)pyridi- n-2-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)piperidin-3-ol; (S)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)piperidin-3-ol; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-m- ethylpyridin-2-yl)piperidin-3-amine; 3-(6-((3S,5R)-3,5-dimethylpiperazin-1-yl)pyridin-2-yl)-5-(1-ethyl-1H-pyra- zol-4-yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)piperidin-3-amine; 3-(6-(3,3-dimethylpiperazin-1-yl)pyridin-2-yl)-5-(1-ethyl-1H-pyrazol-4-yl- )-1H-pyrazolo[3,4-c]pyridine; 3-(6-(6,6-difluoro-1,4-diazepan-1-yl)pyridin-2-yl)-5-(1-ethyl-1H-pyrazol-- 4-yl)-1H-pyrazolo[3,4-c]pyridine; 5-(1-tert-butyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-py- razolo[3,4-c]pyridine; 4-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl- )pyridin-2-yl) morpholine; 4-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl) morpholine; (R)-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyr- idin-2-yl)piperidin-3-ol; cis-4-fluoro-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridi- n-2-yl)piperidin-3-amine; trans-4-fluoro-1-(6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)piperidin-3-amine; (3S,5R)-1-(3-bromo-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyrid- in-3-yl)pyridin-2-yl)-5-fluoropiperidin-3-amine; (3R,5R)-1-(3-bromo-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyrid- in-3-yl)pyridin-2-yl)-5-fluoropiperidin-3-amine; (3S,5R)-1-(3-bromo-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyri- din-3-yl)pyridin-2-yl)-5-fluoropiperidin-3-amine; 3-(6-(1,4-diazepan-1-yl)-4-methylpyridin-2-yl)-5-(1-ethyl-1H-pyrazol-4-yl- )-1H-pyrazolo[3,4-c]pyridine; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-3-methylpiperidin-3-ol; N1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)cyclohexane-1,3-diamine; trans-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)py- ridin-2-yl)-4-fluoropiperidin-3-amine; (4-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)piperazin-2-yl)methanol; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- dine-2-yl)-3-methylpiperidin-3-ol; cis-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-4-fluoropiperidin-3-amine; (S)-1-(5-chloro-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-- 3-yl)pyridin-2-yl)piperidin-3-amine; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(5-(trifluoromethyl)pyridin-3-yl)-1H- -pyrazolo[3,4-c]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(3-(trifluoromethyl)piperazin-1-yl)pyrid- in-2-yl)-1H-pyrazolo[3,4-c]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazo- lo[3,4-c]pyridine; 5-(5-(methylsulfonyl)pyridin-3-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-- pyrazolo[3,4-c]pyridine; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)azepan-4-amine; 1-(4-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyrid- in-2-yl)piperazin-1-yl)ethanone; 2-(4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-- 1H-pyrazol-1-yl)acetonitrile; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-methoxypyridin-2-yl)-1H-pyrazolo[3,4-c]p- yridine; (S)-1-(3-ethyl-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]p- yridin-3-yl)pyridin-2-yl)piperidin-3-amine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-i- sopropylpyridin-2-yl)piperidin-3-amine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyrazin-2-yl)-1H-pyrazol- o[3,4-c]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2- -yl)-1H-pyrazolo[3,4-c]pyridine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)azepan-4-amine; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)-N-methylpiperidin-3-amine; 1-(5-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)p- yridin-3-yl)ethanol; 3-(4-cyclopropylpyridin-2-yl)-5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4- -c]pyridine; (S)-1-(3-cyclopropyl-6-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)p- yridin-2-yl)piperidin-3-amine; (S)-1-(3-cyclopropyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]py- ridin-3-yl)pyridin-2-yl)piperidin-3-amine; 5-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-p- yrazolo[3,4-c]pyridine; 3-(6-(piperazin-1-yl)pyridin-2-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol- -4-yl)-1H-pyrazolo[3,4-c]pyridine; 3-(6-(1,4-diazepan-1-yl)pyridin-2-yl)-5-(1-(2-fluoroethyl)-1H-pyrazol-4-y- l)-1H-pyrazolo[3,4-c]pyridine; 2-(1,4-diazepan-1-yl)-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]py- ridin-3-yl)isonicotinonitrile; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(5-(trifluoromethyl)-1,4-diazepan-1-yl)p- yridin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-methylpyridin-2-yl)-1H-pyrazolo[3,4-c]py- ridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-ethylpyridin-2-yl)-1H-pyrazolo[3,- 4-c]pyridine; 1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)azepan-3-ol; (3S,5R)-5-fluoro-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyr- idin-3-yl)pyridin-2-yl)piperidin-3-amine; 2-(4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-- 1H-pyrazol-1-yl)ethanol; 5-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-3-(6-(piperazin-1-yl)pyridin-2-- yl)-1H-pyrazolo[3,4-c]pyridine; (2-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-4-- yl)methanol; 1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)-1,4-diazepane-6-carbonitrile; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-(prop-1-en-2-yl)pyridin-2-yl)-1H-pyrazol- o[3,4-c]pyridine; (S)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)azepan-3-ol; (R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyri- din-2-yl)azepan-3-ol; (S)-5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-3-(6-(3-methylpiperazin-1-yl)py- ridin-2-yl)-1H-pyrazolo[3,4-c]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(6-(6-fluoro-1,4-diazepan-1-yl)pyridin-2-yl- )-1H-pyrazolo[3,4-c]pyridine; 5-(6-methylpyrazin-2-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3- ,4-c]pyridine; (S)-1-(3-cyclopropyl-6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyr- idin-3-yl)pyridin-2-yl)piperidin-3-amine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(4-isopropylpyridin-2-yl)-1H-pyrazolo[3,4-c- ]pyridine; 5-(1-ethyl-1H-pyrazol-4-yl)-3-(pyridin-2-yl)-1H-pyrazolo[3,4-c]- pyridine; (3S,5R)-5-fluoro-1-(3-methyl-6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-- pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperidin-3-amine; (3S,5R)-1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)- -3-methylpyridin-2-yl)-5-fluoropiperidin-3-amine; (1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)-1,4-diazepan-6-yl)methanol; (1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin- -2-yl)-1,4-diazepan-6-yl)methanol; N-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)azepan-3-amine; 1-(6-(5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-y- l)pyridin-2-yl)azepan-3-amine; 3-ethyl-5-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5- -yl)pyrimidin-4(3H)-one; 5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-3-(6-(3-methylpiperazin-1-yl)pyridi- n-2-yl)-1H-pyrazolo[3,4-c]pyridine; (3R,5R)-5-fluoro-1-(6-(5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyr- idin-3-yl)pyridin-2-yl)piperidin-3-amine; 1-(6-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-- 2-yl)azepan-3-amine; (S)-1-(6-(5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)azepan-3-amine; (R)-1-(6-(5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- -3-yl)pyridin-2-yl)azepan-3-amine; and (R)-5-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-3-(6-(3-methylpiperazin-1-yl)py- ridin-2-yl)-1H-pyrazolo[3,4-c]pyridine. 14. The method of claim 1, wherein said compound is selected from the group consisting of: 3-(6-(1,4-diazepan-1-yl)pyridin-2-yl)-5-(6-methylpyrazin-2-yl)-1H-pyrazol- o[3,4-c]pyridine; 3-(2,5-difluorophenyl)-5-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridine; 4-(3-(2-fluorophenyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-1H-pyrazol-3-amine; 3-(2-fluorophenyl)-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,- 4-c]pyridine; 3-(2-fluorophenyl)-5-(5-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin- e; and 2-(5-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-fluoroanil- ine.

Details for Patent 9,850,239

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2031-08-12
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017		2031-08-12